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- Q4982033 subject Q7164711.
- Q4982033 abstract "In molecular biology, the Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice. Btk is a member of the Tec family of protein tyrosine kinases (PTK). These kinases contain a conserved Tec homology (TH) domain between the N-terminal pleckstrin homology (PH) domain and the Src homology 3 (SH3) domain. The N-terminal of the TH domain is highly conserved and known as the Btf motif, while the C-terminal region of the TH domain contains a proline-rich region (PRR). The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc finger topologies), while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins. The TH domain may be of functional importance in various signalling pathways in different species. A complete TH domain, containing both the Btk and PRR regions, has not been found outside the Tec family; however, the Btk motif on its own does occur in other proteins, usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains are followed by a Btk motif).The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held together by a zinc ion, and that the Btk motif is packed against the PH domain. The zinc-binding residues are a histidine and three cysteines, which are fully conserved in the Btk motif.Proteins known to contain a Btk-type zinc finger include: Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase involved in modulation of diverse cellular processes. Mutations affecting Btk are the cause of X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice.Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily.Drosophila tyrosine-protein kinase Btk29A, which is required for the development of proper ring canals and of male genitalia and required for adult survival.Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to GTP.↑ 1.0 1.1 1.2 ↑ ↑ ↑ ↑".
- Q4982033 symbol "BTK".
- Q4982033 thumbnail PDB_1bwn_EBI.jpg?width=300.
- Q4982033 wikiPageWikiLink Q14906040.
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- Q4982033 wikiPageWikiLink Q484583.
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- Q4982033 wikiPageWikiLink Q5.
- Q4982033 wikiPageWikiLink Q58321.
- Q4982033 wikiPageWikiLink Q620207.
- Q4982033 wikiPageWikiLink Q7164711.
- Q4982033 wikiPageWikiLink Q7202.
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- Q4982033 wikiPageWikiLink Q8047.
- Q4982033 wikiPageWikiLink Q8054.
- Q4982033 wikiPageWikiLink Q828130.
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- Q4982033 wikiPageWikiLink Q901612.
- Q4982033 wikiPageWikiLink Q903495.
- Q4982033 symbol "BTK".
- Q4982033 type Biomolecule.
- Q4982033 type Protein.
- Q4982033 type Thing.
- Q4982033 type Q206229.
- Q4982033 type Q8054.
- Q4982033 comment "In molecular biology, the Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice. Btk is a member of the Tec family of protein tyrosine kinases (PTK).".
- Q4982033 label "Btk-type zinc finger".
- Q4982033 depiction PDB_1bwn_EBI.jpg.