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- Q487493 subject Q52333.
- Q487493 subject Q8732563.
- Q487493 subject Q8873943.
- Q487493 subject Q8879081.
- Q487493 subject Q8919936.
- Q487493 abstract "E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat 5-HT6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist on human 5-HT6 receptors (which are constitutively active). Oral administration of E-6837 reduced food intake, but only transiently. In rats, twice daily administration of E-6837 over the course of 4 weeks resulted in a 15.7% reduction in body weight, compared to 11% reduction for sibutramine. This weight loss remained significant for E-6837 after a 43 day withdrawal period, whereas the weight difference was non-significant for sibutramine (i.e., sibutramine had a rebound effect while E-6837 did not), and this weight loss was found to be due to a loss of fat mass. The reduction in fat mass in E-6837 treated animals was associated with a 50% decrease in plasma leptin levels, and also reduced glucose and insulin levels in plasma after a glucose tolerance test. This indicates that weight loss from E-6837 is associated with improved insulin sensitivity, and thus, better glycemic control. One proposed mechanism of action is that E-6837 acts on neurons in the hypothalamus, which has shown significant levels of 5-HT6 receptor mRNA. The hypothalamus is one key structure involved in regulating food intake.".
- Q487493 iupacName "5-chloro-N-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)naphthalene-2-sulfonamide".
- Q487493 thumbnail E_6837.svg?width=300.
- Q487493 wikiPageWikiLink Q14851942.
- Q487493 wikiPageWikiLink Q1501412.
- Q487493 wikiPageWikiLink Q1640840.
- Q487493 wikiPageWikiLink Q18027448.
- Q487493 wikiPageWikiLink Q208467.
- Q487493 wikiPageWikiLink Q2089287.
- Q487493 wikiPageWikiLink Q21163221.
- Q487493 wikiPageWikiLink Q2255024.
- Q487493 wikiPageWikiLink Q389934.
- Q487493 wikiPageWikiLink Q424151.
- Q487493 wikiPageWikiLink Q487086.
- Q487493 wikiPageWikiLink Q52333.
- Q487493 wikiPageWikiLink Q770260.
- Q487493 wikiPageWikiLink Q8732563.
- Q487493 wikiPageWikiLink Q8873943.
- Q487493 wikiPageWikiLink Q8879081.
- Q487493 wikiPageWikiLink Q8919936.
- Q487493 iupacname "5".
- Q487493 type ChemicalCompound.
- Q487493 type ChemicalSubstance.
- Q487493 type ChemicalObject.
- Q487493 type Thing.
- Q487493 type Q11173.
- Q487493 comment "E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat 5-HT6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist on human 5-HT6 receptors (which are constitutively active). Oral administration of E-6837 reduced food intake, but only transiently.".
- Q487493 label "E-6837".
- Q487493 depiction E_6837.svg.