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- Q4863579 subject Q9089708.
- Q4863579 abstract "In molecular biology, barrier-to-autointegration factor (BAF) is a family of essential proteins that is highly conserved in metazoan evolution, and which may act as DNA-bridging proteins. BAF binds directly to double-stranded DNA, to transcription activators, and to inner nuclear membrane proteins, including lamin A filaments that anchor nuclear pore complexes in place, and nuclear LEM-domain proteins that bind to laminin filaments and chromatin. New findings suggest that BAF has structural roles in nuclear assembly and chromatin organisation, represses gene expression and might interlink chromatin structure, nuclear architecture and gene regulation in metazoans.BAF can be exploited by retroviruses to act as a host component of pre-integration complexes, which promote the integration of the retroviral DNA into the host chromosome by preventing autointegration (integration into itself). BAF might contribute to the assembly or activity of retroviral pre-integration complexes through direct binding to the retroviral proteins p55 Gag and matrix, as well as to DNA.".
- Q4863579 symbol "BAF".
- Q4863579 thumbnail PDB_1ci4_EBI.jpg?width=300.
- Q4863579 wikiPageWikiLink Q14911829.
- Q4863579 wikiPageWikiLink Q177900.
- Q4863579 wikiPageWikiLink Q180951.
- Q4863579 wikiPageWikiLink Q189308.
- Q4863579 wikiPageWikiLink Q26972.
- Q4863579 wikiPageWikiLink Q30679.
- Q4863579 wikiPageWikiLink Q37748.
- Q4863579 wikiPageWikiLink Q411391.
- Q4863579 wikiPageWikiLink Q4995178.
- Q4863579 wikiPageWikiLink Q5611048.
- Q4863579 wikiPageWikiLink Q58345.
- Q4863579 wikiPageWikiLink Q6035658.
- Q4863579 wikiPageWikiLink Q6507061.
- Q4863579 wikiPageWikiLink Q7239240.
- Q4863579 wikiPageWikiLink Q729.
- Q4863579 wikiPageWikiLink Q8054.
- Q4863579 wikiPageWikiLink Q9089708.
- Q4863579 symbol "BAF".
- Q4863579 type Biomolecule.
- Q4863579 type Protein.
- Q4863579 type Thing.
- Q4863579 type Q206229.
- Q4863579 type Q8054.
- Q4863579 comment "In molecular biology, barrier-to-autointegration factor (BAF) is a family of essential proteins that is highly conserved in metazoan evolution, and which may act as DNA-bridging proteins. BAF binds directly to double-stranded DNA, to transcription activators, and to inner nuclear membrane proteins, including lamin A filaments that anchor nuclear pore complexes in place, and nuclear LEM-domain proteins that bind to laminin filaments and chromatin.".
- Q4863579 label "Barrier-to-autointegration factor".
- Q4863579 depiction PDB_1ci4_EBI.jpg.