Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q4803998> ?p ?o }
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- Q4803998 subject Q7211328.
- Q4803998 abstract "Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.Ascomycin is produced by the fermentation of Streptomyces hygroscopicus.".
- Q4803998 atcPrefix "none".
- Q4803998 casNumber "11011-38-4".
- Q4803998 chEBI "29582".
- Q4803998 iupacName "(3S,​4R,​5S,​8R,​9Z,​12S,​14S,​15R,​16S,​18R,​19R,​26aS)-​8-​ethyl-​5,​19-​dihydroxy-​3-​{(E)-​2-​[(1R,​3R,​4R)-​4-​hydroxy-​3-​methoxycyclohexyl]-​1-​methylvinyl}-​14,​16-​dimethoxy-​4,​10,​12,​18-​tetramethyl-​4,​5,​6,​8,​11,​12,​13,​14,​15,​16,​17,​18,​19,​24,​25,​26,​26a-​heptadecahydro-​3H-​15,​19-​epoxypyrido[2,1-c]​[1,4]oxazacyclotriclosine-1,​7,​20,​21(23H)-​tetrone".
- Q4803998 pubchem "5282071".
- Q4803998 thumbnail Ascomycin_structure.png?width=300.
- Q4803998 wikiPageExternalLink 1728_55822.htm.
- Q4803998 wikiPageWikiLink Q105196.
- Q4803998 wikiPageWikiLink Q116672.
- Q4803998 wikiPageWikiLink Q1371525.
- Q4803998 wikiPageWikiLink Q1427096.
- Q4803998 wikiPageWikiLink Q16242752.
- Q4803998 wikiPageWikiLink Q191989.
- Q4803998 wikiPageWikiLink Q212354.
- Q4803998 wikiPageWikiLink Q246809.
- Q4803998 wikiPageWikiLink Q248867.
- Q4803998 wikiPageWikiLink Q3975996.
- Q4803998 wikiPageWikiLink Q411648.
- Q4803998 wikiPageWikiLink Q417489.
- Q4803998 wikiPageWikiLink Q41760.
- Q4803998 wikiPageWikiLink Q5122491.
- Q4803998 wikiPageWikiLink Q6619710.
- Q4803998 wikiPageWikiLink Q7211328.
- Q4803998 wikiPageWikiLink Q8084905.
- Q4803998 atcPrefix "none".
- Q4803998 casNumber "11011".
- Q4803998 chebi "29582".
- Q4803998 iupacName "-​8-​ethyl-​5,​19-​dihydroxy-​3-​{-​2-​[-​4-​hydroxy-​3-​methoxycyclohexyl]-​1-​methylvinyl}-​14,​16-​dimethoxy-​4,​10,​12,​18-​tetramethyl-​4,​5,​6,​8,​11,​12,​13,​14,​15,​16,​17,​18,​19,​24,​25,​26,​26a-​heptadecahydro-​3H-​15,​19-​epoxypyrido[2,1-c]​[1,4]oxazacyclotriclosine-1,​7,​20,​21-​tetrone".
- Q4803998 pubchem "5282071".
- Q4803998 type ChemicalSubstance.
- Q4803998 type Drug.
- Q4803998 type ChemicalObject.
- Q4803998 type Thing.
- Q4803998 type Q8386.
- Q4803998 comment "Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines.".
- Q4803998 label "Ascomycin".
- Q4803998 depiction Ascomycin_structure.png.