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- Q4774650 subject Q7134791.
- Q4774650 abstract "Anticonvulsant/sulfonamide hypersensitivity syndrome is a potentially serious hypersensitivity reaction that can be seen with drugs with an aromatic amine chemical structure, such as aromatic anticonvulsants (e.g. diphenylhydantoin, phenobarbital, phenytoin, carbamazepine, lamotrigine), sulfonamides, or other drugs with an aromatic amine (procainamide). Cross-reactivity should not occur between drugs with an aromatic amine and drugs without an aromatic amine (e.g., sulfonylureas, thiazide diuretics, furosemide, and acetazolamide); therefore, these drugs can be safely used in the future.The hypersensitivity syndrome is characterized by a skin eruption that is initially morbilliform. The rash may also be a severe Stevens-Johnson syndrome or toxic epidermal necrolysis. Systemic manifestations occur at the time of skin manifestations and include eosinophilia, hepatitis, and interstitial nephritis. However, a subgroup of patients may become hypothyroid as part of an autoimmune thyroiditis up to 2 months after the initiation of symptoms.This kind of adverse drug reaction is caused by the accumulation of toxic metabolites; it is not the result of an IgE-mediated reaction. The risk of first-degree relatives’ developing the same hypersensitivity reaction is higher than in the general population.As this syndrome can present secondary to multiple anticonvulsants, the general term "anticonvulsant hypersensitivity syndrome" is favored over the original descriptive term "dilantin hypersensitivity syndrome."".
- Q4774650 icd10 "Y46".
- Q4774650 icd9 "E936".
- Q4774650 wikiPageWikiLink Q1053948.
- Q4774650 wikiPageWikiLink Q131742.
- Q4774650 wikiPageWikiLink Q1424106.
- Q4774650 wikiPageWikiLink Q16501.
- Q4774650 wikiPageWikiLink Q1760689.
- Q4774650 wikiPageWikiLink Q1878682.
- Q4774650 wikiPageWikiLink Q246809.
- Q4774650 wikiPageWikiLink Q3061764.
- Q4774650 wikiPageWikiLink Q3208529.
- Q4774650 wikiPageWikiLink Q388801.
- Q4774650 wikiPageWikiLink Q407595.
- Q4774650 wikiPageWikiLink Q413690.
- Q4774650 wikiPageWikiLink Q417597.
- Q4774650 wikiPageWikiLink Q418776.
- Q4774650 wikiPageWikiLink Q45959.
- Q4774650 wikiPageWikiLink Q4826346.
- Q4774650 wikiPageWikiLink Q505142.
- Q4774650 wikiPageWikiLink Q576618.
- Q4774650 wikiPageWikiLink Q584276.
- Q4774650 wikiPageWikiLink Q5958765.
- Q4774650 wikiPageWikiLink Q653197.
- Q4774650 wikiPageWikiLink Q665843.
- Q4774650 wikiPageWikiLink Q7134791.
- Q4774650 wikiPageWikiLink Q79455.
- Q4774650 wikiPageWikiLink Q949302.
- Q4774650 icd "E936".
- Q4774650 icd "Y46".
- Q4774650 name "Anticonvulsant hypersensitivity syndrome".
- Q4774650 type Disease.
- Q4774650 type Thing.
- Q4774650 type Q12136.
- Q4774650 comment "Anticonvulsant/sulfonamide hypersensitivity syndrome is a potentially serious hypersensitivity reaction that can be seen with drugs with an aromatic amine chemical structure, such as aromatic anticonvulsants (e.g. diphenylhydantoin, phenobarbital, phenytoin, carbamazepine, lamotrigine), sulfonamides, or other drugs with an aromatic amine (procainamide).".
- Q4774650 label "Anticonvulsant hypersensitivity syndrome".
- Q4774650 name "Anticonvulsant hypersensitivity syndrome".