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- Q4770182 subject Q7204727.
- Q4770182 abstract "Anosmin-1 is a secreted, EM associated glycoprotein found in humans and other organisms responsible for normal development, which is expressed in the brain, spinal cord and kidney. Absence or damage to the protein results in Kallmann syndrome in humans, which is characterized by loss of olfactory bulbs and GnRH secretion leading to anosmia and hypothalamic hypogonadotropic hypogonadism. Anosmin-1 is coded by the KAL-1 gene, which is found on the X chromosome. Anosmin-1 is 100 kilodaltons and is expressed on the outside of cells. Because of this and because of its contribution to normal migration of nerve cells, a role in the extracellular matrix has been postulated.During neural crest cell development, anosmin-1 plays a role in cranial neural cell formation by spatiotemporal regulation.Secreated anosmin-1 enhances FGF activity by promoting FGF8-FGFR1 complex formation, whereas inhibits both BMP5 and WNT3A activities. As a results, orchestrated regulation of FGF, BMP, and WNT by anosmin-1 control EMT and MET during neural crest cell development. In human retinal pigment epithelial cell(RPE), the expression of anosmin-1 is regulated by TGF-β which remain to be investigated.".
- Q4770182 wikiPageWikiLink Q1165179.
- Q4770182 wikiPageWikiLink Q1348455.
- Q4770182 wikiPageWikiLink Q14864006.
- Q4770182 wikiPageWikiLink Q1641332.
- Q4770182 wikiPageWikiLink Q164386.
- Q4770182 wikiPageWikiLink Q18048098.
- Q4770182 wikiPageWikiLink Q187126.
- Q4770182 wikiPageWikiLink Q193825.
- Q4770182 wikiPageWikiLink Q385009.
- Q4770182 wikiPageWikiLink Q417310.
- Q4770182 wikiPageWikiLink Q425383.
- Q4770182 wikiPageWikiLink Q43054.
- Q4770182 wikiPageWikiLink Q468433.
- Q4770182 wikiPageWikiLink Q483261.
- Q4770182 wikiPageWikiLink Q5.
- Q4770182 wikiPageWikiLink Q61333.
- Q4770182 wikiPageWikiLink Q6325034.
- Q4770182 wikiPageWikiLink Q644945.
- Q4770182 wikiPageWikiLink Q6821201.
- Q4770182 wikiPageWikiLink Q7204727.
- Q4770182 wikiPageWikiLink Q7239.
- Q4770182 wikiPageWikiLink Q74419.
- Q4770182 wikiPageWikiLink Q815547.
- Q4770182 comment "Anosmin-1 is a secreted, EM associated glycoprotein found in humans and other organisms responsible for normal development, which is expressed in the brain, spinal cord and kidney. Absence or damage to the protein results in Kallmann syndrome in humans, which is characterized by loss of olfactory bulbs and GnRH secretion leading to anosmia and hypothalamic hypogonadotropic hypogonadism. Anosmin-1 is coded by the KAL-1 gene, which is found on the X chromosome.".
- Q4770182 label "Anosmin-1".