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- Q4683181 subject Q8416564.
- Q4683181 subject Q8431779.
- Q4683181 subject Q8529178.
- Q4683181 subject Q8543773.
- Q4683181 subject Q8919936.
- Q4683181 abstract "Adjudin (AF-2364) is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production. It is an analogue of the chemotherapy drug lonidamine, an indazole-carboxylic acid, and further studies continue to be conducted into this family of drugs as possible contraceptives.As of 1 Template:MONTHNAME 2007[[Category:Articles containing potentially dated statements from Template:MONTHNAME 2007]], adjudin was in phase II human trials.As shown in mature male rats, the agent induces reversible germ cell loss from the seminiferous epithelium by disrupting cell adhesion function between Sertoli and germ cells. It weakens the adhesion between the Sertoli cell and maturing sperm leading to a sloughing and loss of the latter. As it does not affect spermatogonia themselves the loss of fertility is reversible. In experiments hormonal levels (FSH, LH, testosterone) were undisturbed during administration, and normal spermatogenesis returned in 95% of the tubules of rats at 210 days after the drug had been discontinued.When taken orally, the drug has very low bioavailability. The oral dose effective for contraception is so high that there have been side effects in the muscles and liver. Coupling an Adjudin molecule to a mutant form of follicle-stimulating hormone may solve this problem. The mutant FSH is modified such that it no longer induces Inhibin B production, but the membrane-bound FSH receptors on Sertoli cells still bind to it, delivering the Adjudin directly to the target cells. The adjudin-FSH can be either injected, delivered in an implant, or as a gel.A study in 2013 indicated that Adjudin, similar to its analogue lonidamine, has properties that inhibit cancer growth by targeting mitochondria and blocking energy metabolism in certain kinds of tumor cells in mice, indicating that it has potential as a drug for cancer therapy.".
- Q4683181 atcPrefix "none".
- Q4683181 casNumber "252025-52-8".
- Q4683181 iupacName "1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide".
- Q4683181 pubchem "9819086".
- Q4683181 thumbnail Adjudin_structure.png?width=300.
- Q4683181 wikiPageExternalLink 6091582.stm.
- Q4683181 wikiPageExternalLink article1940823.ece.
- Q4683181 wikiPageExternalLink others.php.
- Q4683181 wikiPageWikiLink Q12078.
- Q4683181 wikiPageWikiLink Q1318776.
- Q4683181 wikiPageWikiLink Q17145.
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- Q4683181 wikiPageWikiLink Q200774.
- Q4683181 wikiPageWikiLink Q208360.
- Q4683181 wikiPageWikiLink Q281579.
- Q4683181 wikiPageWikiLink Q36961.
- Q4683181 wikiPageWikiLink Q3836670.
- Q4683181 wikiPageWikiLink Q422284.
- Q4683181 wikiPageWikiLink Q461809.
- Q4683181 wikiPageWikiLink Q74560.
- Q4683181 wikiPageWikiLink Q8386.
- Q4683181 wikiPageWikiLink Q8416564.
- Q4683181 wikiPageWikiLink Q8431779.
- Q4683181 wikiPageWikiLink Q8529178.
- Q4683181 wikiPageWikiLink Q8543773.
- Q4683181 wikiPageWikiLink Q8919936.
- Q4683181 wikiPageWikiLink Q9384.
- Q4683181 wikiPageWikiLink Q949861.
- Q4683181 atcPrefix "none".
- Q4683181 casNumber "252025".
- Q4683181 iupacName "1".
- Q4683181 pubchem "9819086".
- Q4683181 type ChemicalSubstance.
- Q4683181 type Drug.
- Q4683181 type ChemicalObject.
- Q4683181 type Thing.
- Q4683181 type Q8386.
- Q4683181 comment "Adjudin (AF-2364) is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.".
- Q4683181 label "Adjudin".
- Q4683181 depiction Adjudin_structure.png.