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- Q4677599 subject Q7081681.
- Q4677599 subject Q7130307.
- Q4677599 subject Q7400289.
- Q4677599 subject Q8351281.
- Q4677599 subject Q8638071.
- Q4677599 subject Q9094579.
- Q4677599 abstract "The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make contact through structures called synapses allowing them to communicate with each other. As shown in the diagram on the right, a synapse consists of the presynaptic bouton of one neuron which stores vesicles containing neurotransmitter (uppermost in the picture) and a second, postsynaptic neuron which bears receptors for the neurotransmitter (at the bottom). When an action potential reaches the presynaptic bouton, the contents of the vesicles are released into the synaptic cleft and the released neurotransmitter travels across the cleft to the postsynaptic neuron (the lower structure in the picture) and activates the receptors on the postsynaptic membrane.The active zone is the region in the presynaptic bouton that mediates neurotransmitter release and is composed of the presynaptic membrane and a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ is seen under the electron microscope to be a dark (electron dense) area close to the membrane. Proteins within the CAZ tether synaptic vesicles to the presynaptic membrane and mediate synaptic vesicle fusion, thereby allowing neurotransmitter to be released reliably and rapidly when an action potential arrives.".
- Q4677599 thumbnail Neuron_synapse.png?width=300.
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- Q4677599 name "Active zone".
- Q4677599 type AnatomicalStructure.
- Q4677599 type Thing.
- Q4677599 type Q4936952.
- Q4677599 comment "The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make contact through structures called synapses allowing them to communicate with each other.".
- Q4677599 label "Active zone".
- Q4677599 depiction Neuron_synapse.png.
- Q4677599 name "Active zone".