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- Q4652514 subject Q7334131.
- Q4652514 subject Q8217658.
- Q4652514 subject Q8334258.
- Q4652514 subject Q8529178.
- Q4652514 subject Q8919936.
- Q4652514 subject Q8978033.
- Q4652514 subject Q9092837.
- Q4652514 abstract "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the CB1 receptor (with a Ki value of 7.5nM) than SR141716A, which has a Ki value of 11.5nM, AM-251 is, however, about two-fold more selective for the CB1 receptor when compared to SR141716A. Like SR141716A, it is additionally a μ-opioid receptor antagonist.".
- Q4652514 casNumber "183232-66-8".
- Q4652514 chEBI "90724".
- Q4652514 iupacName "1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-".
- Q4652514 iupacName "N-(1-piperidyl)pyrazole-3-carboxamide".
- Q4652514 pubchem "2125".
- Q4652514 thumbnail AM2512d.png?width=300.
- Q4652514 wikiPageWikiLink Q1103.
- Q4652514 wikiPageWikiLink Q1671731.
- Q4652514 wikiPageWikiLink Q21163314.
- Q4652514 wikiPageWikiLink Q355679.
- Q4652514 wikiPageWikiLink Q408908.
- Q4652514 wikiPageWikiLink Q410234.
- Q4652514 wikiPageWikiLink Q412529.
- Q4652514 wikiPageWikiLink Q422936.
- Q4652514 wikiPageWikiLink Q43413.
- Q4652514 wikiPageWikiLink Q4407.
- Q4652514 wikiPageWikiLink Q5032579.
- Q4652514 wikiPageWikiLink Q688.
- Q4652514 wikiPageWikiLink Q7334131.
- Q4652514 wikiPageWikiLink Q8217658.
- Q4652514 wikiPageWikiLink Q8334258.
- Q4652514 wikiPageWikiLink Q8529178.
- Q4652514 wikiPageWikiLink Q8919936.
- Q4652514 wikiPageWikiLink Q8978033.
- Q4652514 wikiPageWikiLink Q898254.
- Q4652514 wikiPageWikiLink Q9092837.
- Q4652514 casNumber "183232".
- Q4652514 chebi "90724".
- Q4652514 iupacName "1".
- Q4652514 iupacName "N-pyrazole-3-carboxamide".
- Q4652514 pubchem "2125".
- Q4652514 type ChemicalSubstance.
- Q4652514 type Drug.
- Q4652514 type ChemicalObject.
- Q4652514 type Thing.
- Q4652514 type Q8386.
- Q4652514 comment "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group.".
- Q4652514 label "AM251".
- Q4652514 depiction AM2512d.png.