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- Q4652492 subject Q5920511.
- Q4652492 subject Q7139608.
- Q4652492 subject Q8217658.
- Q4652492 subject Q8297699.
- Q4652492 subject Q8341873.
- Q4652492 abstract "AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry. This gives AM-4030 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB1, with a Ki of 0.7nM at CB1 and 8.6nM at CB2, a selectivity of around 12x. Resolution of the enantiomers of AM-4030 yields an even more potent compound, although with less selectivity, with the (-) enantiomer AM-4030a having a Ki of 0.6nM at CB1 and 1.1nM at CB2.".
- Q4652492 casNumber "587023-54-9".
- Q4652492 iupacName "(6S,6aR,9R,10aR)-9-(hydroxymethyl)-6-[(E)-3-hydroxyprop-1-enyl]-6-methyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol".
- Q4652492 pubchem "10550598".
- Q4652492 thumbnail AM-4030.png?width=300.
- Q4652492 wikiPageWikiLink Q104116.
- Q4652492 wikiPageWikiLink Q173235.
- Q4652492 wikiPageWikiLink Q17907844.
- Q4652492 wikiPageWikiLink Q186011.
- Q4652492 wikiPageWikiLink Q192596.
- Q4652492 wikiPageWikiLink Q21163314.
- Q4652492 wikiPageWikiLink Q258652.
- Q4652492 wikiPageWikiLink Q411899.
- Q4652492 wikiPageWikiLink Q411905.
- Q4652492 wikiPageWikiLink Q422936.
- Q4652492 wikiPageWikiLink Q4652507.
- Q4652492 wikiPageWikiLink Q4652508.
- Q4652492 wikiPageWikiLink Q5920511.
- Q4652492 wikiPageWikiLink Q7139608.
- Q4652492 wikiPageWikiLink Q8217658.
- Q4652492 wikiPageWikiLink Q8297699.
- Q4652492 wikiPageWikiLink Q8341873.
- Q4652492 wikiPageWikiLink Q898254.
- Q4652492 casNumber "587023".
- Q4652492 iupacName "-9".
- Q4652492 pubchem "10550598".
- Q4652492 type ChemicalSubstance.
- Q4652492 type Drug.
- Q4652492 type ChemicalObject.
- Q4652492 type Thing.
- Q4652492 type Q8386.
- Q4652492 comment "AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry.".
- Q4652492 label "AM-4030".
- Q4652492 depiction AM-4030.png.