Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q4651113> ?p ?o }
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- Q4651113 subject Q13259243.
- Q4651113 subject Q8431759.
- Q4651113 abstract "ADH-1 (brand name Exherin) is a small, cyclic pentapeptide vascular-targeting drug.ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell–cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.In a pilot study (phase I trial) at Duke Comprehensive Cancer Center, ADH-1 intravenous pretreatment before chemotherapy in metastatic melanoma completely destroyed tumors in half the patients, normally a very deadly cancer. It is being investigated for advanced extremity melanoma in phase II trials.".
- Q4651113 thumbnail ADH-1.svg?width=300.
- Q4651113 wikiPageWikiLink Q13259243.
- Q4651113 wikiPageWikiLink Q14599311.
- Q4651113 wikiPageWikiLink Q166886.
- Q4651113 wikiPageWikiLink Q17859798.
- Q4651113 wikiPageWikiLink Q180614.
- Q4651113 wikiPageWikiLink Q187640.
- Q4651113 wikiPageWikiLink Q369541.
- Q4651113 wikiPageWikiLink Q500446.
- Q4651113 wikiPageWikiLink Q6953133.
- Q4651113 wikiPageWikiLink Q7180990.
- Q4651113 wikiPageWikiLink Q8431759.
- Q4651113 wikiPageWikiLink Q974135.
- Q4651113 type ChemicalSubstance.
- Q4651113 type Drug.
- Q4651113 type ChemicalObject.
- Q4651113 type Thing.
- Q4651113 type Q8386.
- Q4651113 comment "ADH-1 (brand name Exherin) is a small, cyclic pentapeptide vascular-targeting drug.ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.".
- Q4651113 label "ADH-1".
- Q4651113 depiction ADH-1.svg.