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- Q4650509 subject Q7213592.
- Q4650509 abstract "Human acetyl-coA cholesterol acyltransferase (ACAT1) gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7. This chimeric mRNA uses AUG as a translation initiation codon to produce the normal 50-kDa ACAT1 protein but used an alternative translation initiation codon, GGC, to produce the novel enzymatically active 56-kDa isoform.Mutagenesis and mass spectrometry identified the alternative initiation codon as the start codon for the novel 56-kDa protein and its location was mapped to a region located upstream of the AUG initiation codon. Three stem loop structures have been predicted to surround the GCC initiation codon and are known as SL1 to SL3. Mutations that disrupted these stem-loop structures showed that SL1 and SL2 as required for translation initiation from the GGC codon but SL3 has no effect on translation efficiency. Translation initiation from the GGC codon was shown to be is mediated by an internal ribosome entry site (IRES) which requires SL1 located upstream of the IRES and SL2 located downstream. This study also showed that SL3 influences the choice of downstream AUG translation initiation codons that will produce the normal 50-KDa human ACAT1 protein.".
- Q4650509 thumbnail ACAT_SS.png?width=300.
- Q4650509 wikiPageWikiLink Q11053.
- Q4650509 wikiPageWikiLink Q14913201.
- Q4650509 wikiPageWikiLink Q149299.
- Q4650509 wikiPageWikiLink Q15712714.
- Q4650509 wikiPageWikiLink Q166992.
- Q4650509 wikiPageWikiLink Q180809.
- Q4650509 wikiPageWikiLink Q1854186.
- Q4650509 wikiPageWikiLink Q185917.
- Q4650509 wikiPageWikiLink Q188928.
- Q4650509 wikiPageWikiLink Q37748.
- Q4650509 wikiPageWikiLink Q418900.
- Q4650509 wikiPageWikiLink Q425158.
- Q4650509 wikiPageWikiLink Q483261.
- Q4650509 wikiPageWikiLink Q7213592.
- Q4650509 wikiPageWikiLink Q8047.
- Q4650509 comment "Human acetyl-coA cholesterol acyltransferase (ACAT1) gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7.".
- Q4650509 label "ACAT1 mRNA".
- Q4650509 depiction ACAT_SS.png.