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- Q4641530 subject Q52363.
- Q4641530 subject Q8297708.
- Q4641530 subject Q8375173.
- Q4641530 subject Q8418517.
- Q4641530 abstract "6-(2-Aminopropyl)-2,3-dihydrobenzofuran (6-APDB, 4-Desoxy-MDA, EMA-3) is a stimulant and entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of MDA where the heterocyclic 4-position oxygen from the 3,4-methylenedioxy ring has been replaced with a methylene bridge. 5-APDB (3-Desoxy-MDA) is an analogue of 6-APDB where the 3-position oxygen has been replaced with a methylene instead. 6-APDB, along with 5-APDB, was first synthesized by David E. Nichols in the early 1990s while investigating non-neurotoxic MDMA analogues.In animal studies, 6-APDB fully substitutes for MBDB and MMAI but not for amphetamine or LSD. In vitro, 6-APDB has been shown to inhibit the reuptake of serotonin, dopamine, and norepinephrine with IC50 values of 322 nM, 1,997 nM, and 980 nM, respectively. These values are very similar to those of MDA, but with those for the catecholamines slightly lower in comparison, perhaps more similarly to MDMA. In contrast, 5-APDB is highly selective for serotonin. Though 6-APDB does not substitute for amphetamine in rats at the doses used in referenced study, based on its in vitro profile it can be suggested that it may have amphetamine-like effects at higher doses.The unsaturated benzofuran derivative 6-APB, or 6-(2-aminopropyl)benzofuran is also known, but the difference in pharmacological effects between 6-APB and 6-APDB is unclear.6-APDB is a class B drug in the UK since June 10, 2013. It is banned by a blanket law on benzofurans and related compounds.".
- Q4641530 atcPrefix "none".
- Q4641530 casNumber "152623-93-3".
- Q4641530 iupacName "1-(2,3-dihydro-1-benzofuran-6-yl)propan-2-amine".
- Q4641530 pubchem "192599".
- Q4641530 thumbnail 4-desoxy-MDA.svg?width=300.
- Q4641530 wikiPageWikiLink Q1153832.
- Q4641530 wikiPageWikiLink Q12746290.
- Q4641530 wikiPageWikiLink Q15409380.
- Q4641530 wikiPageWikiLink Q167934.
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- Q4641530 wikiPageWikiLink Q170409.
- Q4641530 wikiPageWikiLink Q179452.
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- Q4641530 wikiPageWikiLink Q193430.
- Q4641530 wikiPageWikiLink Q211036.
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- Q4641530 wikiPageWikiLink Q23118.
- Q4641530 wikiPageWikiLink Q2445303.
- Q4641530 wikiPageWikiLink Q2664395.
- Q4641530 wikiPageWikiLink Q271663.
- Q4641530 wikiPageWikiLink Q286779.
- Q4641530 wikiPageWikiLink Q3017818.
- Q4641530 wikiPageWikiLink Q3338704.
- Q4641530 wikiPageWikiLink Q416405.
- Q4641530 wikiPageWikiLink Q422693.
- Q4641530 wikiPageWikiLink Q4639556.
- Q4641530 wikiPageWikiLink Q4639568.
- Q4641530 wikiPageWikiLink Q4639569.
- Q4641530 wikiPageWikiLink Q4639572.
- Q4641530 wikiPageWikiLink Q4641531.
- Q4641530 wikiPageWikiLink Q485014.
- Q4641530 wikiPageWikiLink Q4859664.
- Q4641530 wikiPageWikiLink Q52363.
- Q4641530 wikiPageWikiLink Q5322853.
- Q4641530 wikiPageWikiLink Q629.
- Q4641530 wikiPageWikiLink Q6823973.
- Q4641530 wikiPageWikiLink Q6823980.
- Q4641530 wikiPageWikiLink Q69488.
- Q4641530 wikiPageWikiLink Q8297708.
- Q4641530 wikiPageWikiLink Q8375173.
- Q4641530 wikiPageWikiLink Q8386.
- Q4641530 wikiPageWikiLink Q8418517.
- Q4641530 wikiPageWikiLink Q903338.
- Q4641530 wikiPageWikiLink Q910028.
- Q4641530 atcPrefix "none".
- Q4641530 casNumber "152623".
- Q4641530 iupacName "1".
- Q4641530 pubchem "192599".
- Q4641530 type ChemicalSubstance.
- Q4641530 type Drug.
- Q4641530 type ChemicalObject.
- Q4641530 type Thing.
- Q4641530 type Q8386.
- Q4641530 comment "6-(2-Aminopropyl)-2,3-dihydrobenzofuran (6-APDB, 4-Desoxy-MDA, EMA-3) is a stimulant and entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of MDA where the heterocyclic 4-position oxygen from the 3,4-methylenedioxy ring has been replaced with a methylene bridge. 5-APDB (3-Desoxy-MDA) is an analogue of 6-APDB where the 3-position oxygen has been replaced with a methylene instead. 6-APDB, along with 5-APDB, was first synthesized by David E.".
- Q4641530 label "6-APDB".
- Q4641530 depiction 4-desoxy-MDA.svg.