Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q4637186> ?p ?o }
Showing triples 1 to 29 of
29
with 100 triples per page.
- Q4637186 subject Q18924462.
- Q4637186 subject Q8341873.
- Q4637186 subject Q8590801.
- Q4637186 abstract "4-O-Methylhonokiol is a neolignan, a type of phenolic compounds. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers.4-O-Methylhonokiol is a potent CB2 receptor ligand (Ki = 50 nM), showing a unique inverse agonism and partial agonism via different pathways (cAMP and Ca2+) and potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective and anti-Alzheimer Disease effects reported in rodent models may be mediated via CB2 receptors, providing that the compound should be orally bioavailable to the brain. It was shown that 4-O-methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects at CB receptors. The same study also provided data that this natural product can readily pass the blood–brain barrier, using LC-MS/MS.".
- Q4637186 iupacName "2-(4-Methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol".
- Q4637186 thumbnail Methylhonokiol.svg?width=300.
- Q4637186 wikiPageWikiLink Q161116.
- Q4637186 wikiPageWikiLink Q1671731.
- Q4637186 wikiPageWikiLink Q17070966.
- Q4637186 wikiPageWikiLink Q17907844.
- Q4637186 wikiPageWikiLink Q18030834.
- Q4637186 wikiPageWikiLink Q1859063.
- Q4637186 wikiPageWikiLink Q18924462.
- Q4637186 wikiPageWikiLink Q424634.
- Q4637186 wikiPageWikiLink Q502961.
- Q4637186 wikiPageWikiLink Q770260.
- Q4637186 wikiPageWikiLink Q8341873.
- Q4637186 wikiPageWikiLink Q8590801.
- Q4637186 iupacname "2".
- Q4637186 name "4".
- Q4637186 type ChemicalCompound.
- Q4637186 type ChemicalSubstance.
- Q4637186 type ChemicalObject.
- Q4637186 type Thing.
- Q4637186 type Q11173.
- Q4637186 comment "4-O-Methylhonokiol is a neolignan, a type of phenolic compounds. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers.4-O-Methylhonokiol is a potent CB2 receptor ligand (Ki = 50 nM), showing a unique inverse agonism and partial agonism via different pathways (cAMP and Ca2+) and potently inhibits osteoclastogenesis.".
- Q4637186 label "4-O-Methylhonokiol".
- Q4637186 depiction Methylhonokiol.svg.
- Q4637186 name "4-O-Methylhonokiol".