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- Q44793 subject Q8210704.
- Q44793 abstract "PRX-08066 is a drug discovered and developed by Predix (later Epix) Pharmaceuticals [Dale S. Dhanoa et al. Patent US 7,030,240 B2], which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with a 5-HT2B binding affinity (Ki) of 3.4nM, and high selectivity over the closely related 5-HT2A and 5-HT2C receptors and other receptor targets. PRX-08066 and other selective 5-HT2B antagonists are being researched for the treatment of pulmonary arterial hypertension, following the discovery that the potent 5-HT2B agonist norfenfluramine produces pulmonary arterial hypertension and subsequent heart valve damage. In animal studies, PRX-08066 has been found to reduce several key indicators of pulmonary arterial hypertension and improved cardiac output, with similar efficacy to established drugs for this condition such as bosentan, sildenafil, beraprost and iloprost. It is also being researched for potential anti-cancer applications, due to its ability to inhibit fibroblast activation.".
- Q44793 iupacName "5-((4-(6-chlorothieno[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile".
- Q44793 pubchem "11502243".
- Q44793 thumbnail PRX-08066_structure.png?width=300.
- Q44793 wikiPageWikiLink Q1128595.
- Q44793 wikiPageWikiLink Q14891424.
- Q44793 wikiPageWikiLink Q167934.
- Q44793 wikiPageWikiLink Q18027434.
- Q44793 wikiPageWikiLink Q18027437.
- Q44793 wikiPageWikiLink Q191521.
- Q44793 wikiPageWikiLink Q208467.
- Q44793 wikiPageWikiLink Q2718713.
- Q44793 wikiPageWikiLink Q3069482.
- Q44793 wikiPageWikiLink Q410943.
- Q44793 wikiPageWikiLink Q419769.
- Q44793 wikiPageWikiLink Q463418.
- Q44793 wikiPageWikiLink Q5977854.
- Q44793 wikiPageWikiLink Q8210704.
- Q44793 wikiPageWikiLink Q898254.
- Q44793 iupacName "5".
- Q44793 pubchem "11502243".
- Q44793 type ChemicalSubstance.
- Q44793 type Drug.
- Q44793 type ChemicalObject.
- Q44793 type Thing.
- Q44793 type Q8386.
- Q44793 comment "PRX-08066 is a drug discovered and developed by Predix (later Epix) Pharmaceuticals [Dale S. Dhanoa et al. Patent US 7,030,240 B2], which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with a 5-HT2B binding affinity (Ki) of 3.4nM, and high selectivity over the closely related 5-HT2A and 5-HT2C receptors and other receptor targets.".
- Q44793 label "PRX-08066".
- Q44793 depiction PRX-08066_structure.png.