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- Q442466 subject Q5312304.
- Q442466 subject Q6967136.
- Q442466 subject Q7013344.
- Q442466 subject Q7030852.
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- Q442466 subject Q8266462.
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- Q442466 subject Q9699479.
- Q442466 abstract "Alexander Jacob Varshavsky (Russian: Александр Яковлевич Варшавский; born 8 November 1946) is a Russian-American biochemist, noted for his discovery of the N-end rule of ubiquitination. A native of Moscow, he is currently researching at Caltech.Varshavsky provided an original approach to killing cancer cells, proffering the idea of a targeted molecular device that could enter a cell, examine it for DNA deletions specific to cancer and killing it if it meets the right profile. "(It) involves, in a nutshell, the finding of a genuine Achilles' heel of cancer cells, i.e. their potentially vulnerable feature that won't change during tumor progression," said Varshavsky.The approach termed deletion-specific targeting (DST), employs HDs (homozygous DNA deletions) as the targets of cancer therapy. "In contrast to other attributes of cancer cells, their HDs are immutable markers. If the DST strategy can be implemented in a clinical setting, it may prove to be both curative and free of side effects."".
- Q442466 wikiPageExternalLink Varshavsky.
- Q442466 wikiPageExternalLink www.gothamprize.org.
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- Q442466 wikiPageWikiLink Q5312304.
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- Q442466 wikiPageWikiLink Q9699479.
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- Q442466 type Thing.
- Q442466 comment "Alexander Jacob Varshavsky (Russian: Александр Яковлевич Варшавский; born 8 November 1946) is a Russian-American biochemist, noted for his discovery of the N-end rule of ubiquitination. A native of Moscow, he is currently researching at Caltech.Varshavsky provided an original approach to killing cancer cells, proffering the idea of a targeted molecular device that could enter a cell, examine it for DNA deletions specific to cancer and killing it if it meets the right profile.".
- Q442466 label "Alexander Varshavsky".