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- Q4327722 subject Q16813793.
- Q4327722 subject Q7440858.
- Q4327722 abstract "Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). It is derived from the prepronociceptin protein, as are a further 2 peptides, nocistatin & NocII. The gene coding for prepronociceptin is located on Ch8p21 in humans.Nociceptin acts at the Nociceptin receptor (NOP receptor) formerly known as ORL1. Nociceptin is the first example of reverse pharmacology; the NOP receptor was discovered before the endogenous ligand which was discovered by two separate groups in 1995. Nociceptin is an opioid-related peptide, but it does not act at the classic opioid receptors (namely, mu, kappa, and delta opioid receptors), and its actions are not antagonized by the opioid antagonist naloxone. Nociceptin is a potent anti-analgesic. Nociceptin is widely distributed in the CNS; it is found in many regions of the hypothalamus, brainstem, and forebrain, as well as in the ventral horn and dorsal horn of the spinal cord. The NOP receptor is also widely distributed in the brain, including in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central gray, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus, and spinal cord.".
- Q4327722 thumbnail Nociceptin.png?width=300.
- Q4327722 wikiPageWikiLink Q1243765.
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- Q4327722 wikiPageWikiLink Q16813793.
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- Q4327722 wikiPageWikiLink Q7187.
- Q4327722 wikiPageWikiLink Q7234198.
- Q4327722 wikiPageWikiLink Q7440858.
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- Q4327722 wikiPageWikiLink Q9606.
- Q4327722 arm "p".
- Q4327722 band "21".
- Q4327722 chromosome "8".
- Q4327722 entrezgene "5368".
- Q4327722 hgncid "9163".
- Q4327722 name "prepronociceptin".
- Q4327722 omim "601459".
- Q4327722 refseq "NM_006228".
- Q4327722 symbol "PNOC".
- Q4327722 uniprot "Q13519".
- Q4327722 type ChemicalCompound.
- Q4327722 type ChemicalSubstance.
- Q4327722 type ChemicalObject.
- Q4327722 type Thing.
- Q4327722 type Q11173.
- Q4327722 comment "Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). It is derived from the prepronociceptin protein, as are a further 2 peptides, nocistatin & NocII. The gene coding for prepronociceptin is located on Ch8p21 in humans.Nociceptin acts at the Nociceptin receptor (NOP receptor) formerly known as ORL1.".
- Q4327722 label "Nociceptin".
- Q4327722 depiction Nociceptin.png.