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- Q426772 subject Q7348588.
- Q426772 subject Q8395789.
- Q426772 abstract "Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface. Many sheddases are members of the ADAM or aspartic protease (BACE) protein families.These enzymes can activate a transmembrane protein if it is a receptor (e.g., HER2), or cut off the part of the transmembrane protein which has already bound an agonist (e.g., in the case of EGFR), allowing this agonist to go and stimulate a receptor on another cell. Hence, sheddases demultiply the yield of agonists. Sheddase inhibitors active on ADAM10 and ADAM17 can potentiate anti-cancer therapy.".
- Q426772 thumbnail Ectodomain_shedding_en.svg?width=300.
- Q426772 wikiPageWikiLink Q14865565.
- Q426772 wikiPageWikiLink Q14877486.
- Q426772 wikiPageWikiLink Q14891871.
- Q426772 wikiPageWikiLink Q14907942.
- Q426772 wikiPageWikiLink Q17709536.
- Q426772 wikiPageWikiLink Q290049.
- Q426772 wikiPageWikiLink Q424204.
- Q426772 wikiPageWikiLink Q5333998.
- Q426772 wikiPageWikiLink Q7251227.
- Q426772 wikiPageWikiLink Q7348588.
- Q426772 wikiPageWikiLink Q8047.
- Q426772 wikiPageWikiLink Q8395789.
- Q426772 comment "Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface.".
- Q426772 label "Sheddase".
- Q426772 depiction Ectodomain_shedding_en.svg.