Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q425894> ?p ?o }
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- Q425894 subject Q6865951.
- Q425894 subject Q7145140.
- Q425894 subject Q7311092.
- Q425894 subject Q7427150.
- Q425894 subject Q8515266.
- Q425894 abstract "Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some potential as an anti-cancer drug. One suggested mechanism is that TSA promotes the expression of apoptosis-related genes, leading to cancerous cells surviving at lower rates, thus slowing the progression of cancer. Other mechanisms may include the activity of HDIs to induce cell differentiation, thus acting to "mature" some of the de-differentiated cells found in tumors. HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time.TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.TSA represses IL (interleukin)-1β/LPS (lipopolysaccharide)/IFNγ (interferon γ)-induced nitric oxide synthase (NOS)2 expression in murine macrophage-like cells but increases LPS-stimulated NOS2 expression in murine N9 and primary rat microglial cells.TSA has not been tested in clinical trials as of 2013-05-27.".
- Q425894 atcPrefix "none".
- Q425894 casNumber "58880-19-6".
- Q425894 chEBI "46024".
- Q425894 drugbank "DB04297".
- Q425894 iupacName "7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide".
- Q425894 pubchem "444732".
- Q425894 thumbnail Trichostatin_A.svg?width=300.
- Q425894 wikiPageExternalLink trichostatin_A-MSDS.htm.
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- Q425894 wikiPageWikiLink Q180951.
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- Q425894 wikiPageWikiLink Q6865951.
- Q425894 wikiPageWikiLink Q7145140.
- Q425894 wikiPageWikiLink Q7187.
- Q425894 wikiPageWikiLink Q7311092.
- Q425894 wikiPageWikiLink Q7427150.
- Q425894 wikiPageWikiLink Q7430.
- Q425894 wikiPageWikiLink Q8047.
- Q425894 wikiPageWikiLink Q8515266.
- Q425894 wikiPageWikiLink Q905901.
- Q425894 atcPrefix "none".
- Q425894 casNumber "58880".
- Q425894 chebi "46024".
- Q425894 drugbank "DB04297".
- Q425894 iupacName "7".
- Q425894 pubchem "444732".
- Q425894 type ChemicalSubstance.
- Q425894 type Drug.
- Q425894 type ChemicalObject.
- Q425894 type Thing.
- Q425894 type Q8386.
- Q425894 comment "Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage.".
- Q425894 label "Trichostatin A".
- Q425894 depiction Trichostatin_A.svg.