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- Q425134 subject Q7773984.
- Q425134 subject Q8444066.
- Q425134 subject Q8552222.
- Q425134 subject Q8707756.
- Q425134 subject Q8844622.
- Q425134 subject Q8844623.
- Q425134 subject Q8880051.
- Q425134 subject Q9532257.
- Q425134 abstract "Palytoxin is an intense vasoconstrictor, and is considered to be one of the most toxic non-protein substances known, second only to maitotoxin in terms of toxicity in mice. Palytoxin is a natural compound, (chemically a fatty alcohol) that is produced by several marine species and can be found in many more species due to a process known as biomagnification.Palytoxin was originally isolated in 1971 in Hawaii from the seaweed-like coral "limu-make-o-Hana" (Seaweed of Death from Hana). Later, in 1982 its full chemical structure was published by Prof. Daisuke Uemura and co-workers at Nagoya University. Yoshito Kishi's group at Harvard University first synthesized palytoxin in 1994. Palytoxin targets the sodium-potassium pump protein by locking it into a position where it allows passive transport of both sodium and potassium ions, thereby destroying the ion gradient that is essential for most cells.Because palytoxin affects every cell in the body, the symptoms are very different for the various routes of exposure. The most common exposure in humans is by ingestion or inhalation. The onset of symptoms is rapid, and death usually follows quickly.".
- Q425134 iupacName "(2S,3R,5R,6E,8R,9S)-10-[(2R,3R,4R,5S,6R)-6-[(1S,2R,3S,4S,5R,11S)-11-{[(1R,3S,5S,7R)-5-[(8S)-9-[(2R,3R,4R,5R,6S)-6-[(2S,3S,4E,6S,9R,10R)-10-[(2S,4R,5S,6R)-6-[(2R,3R)-4-[(2R,3S,4R,5R,6S)-6-[(2S,3Z,5E,8R,9S,10R,12Z,17S,18R,19R,20R)-20-{[(2R,3R,4R,5S,6R)-6-[(1Z,3R,4R)-5-[(1S,3R,5R,7R)-7-{2-[(2R,3R,5S)-5-(aminomethyl)-3-hydroxyoxolan-2-yl]ethyl}-2,6-dioxabicyclo[3.2.1]octan-3-yl]-3,4-dihydroxypent-1-en-1-yl]-3,4,5-trihydroxyoxan-2-yl]methyl}-2,8,9,10,17,18,19-heptahydroxy-14-methylidenehenicosa-3,5,12-trien-1-yl]-3,4,5-trihydroxyoxan-2-yl]-2,3-dihydroxybutyl]-4,5-dihydroxyoxan-2-yl]-2,6,9,10-tetrahydroxy-3-methyldec-4-en-1-yl]-3,4,5,6-tetrahydroxyoxan-2-yl]-8-hydroxynonyl]-1,3-dimethyl-6,8-dioxabicyclo[3.2.1]octan-7-yl]methyl}-1,2,3,4,5-pentahydroxydodecyl]-3,4,5-trihydroxyoxan-2-yl]-2,5,8,9-tetrahydroxy-N-[(1E)-2-[(3-hydroxypropyl)-C-hydroxycarbonimidoyl]eth-1-en-1-yl]-3,7-dimethyldec-6-enimidic acid".
- Q425134 thumbnail Palytoxin.svg?width=300.
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- Q425134 iupacname "-10".
- Q425134 type ChemicalCompound.
- Q425134 type ChemicalSubstance.
- Q425134 type ChemicalObject.
- Q425134 type Thing.
- Q425134 type Q11173.
- Q425134 comment "Palytoxin is an intense vasoconstrictor, and is considered to be one of the most toxic non-protein substances known, second only to maitotoxin in terms of toxicity in mice. Palytoxin is a natural compound, (chemically a fatty alcohol) that is produced by several marine species and can be found in many more species due to a process known as biomagnification.Palytoxin was originally isolated in 1971 in Hawaii from the seaweed-like coral "limu-make-o-Hana" (Seaweed of Death from Hana).".
- Q425134 label "Palytoxin".
- Q425134 depiction Palytoxin.svg.