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- Q424611 subject Q7214357.
- Q424611 subject Q7403984.
- Q424611 subject Q8255706.
- Q424611 abstract "Glucagon-like peptide-1 (GLP-1) is a neuropeptide and an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the periphery is the intestinal L cell that secretes GLP-1 as a gut hormone; the major source in the brain is the nucleus of the solitary tract, which is the source of a widely distributed set of GLP-1 projection neurons. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2. Those peptides result from selective cleavage of the proglucagon molecule.GLP-1 secretion by ileal L cells is dependent on the presence of nutrients in the lumen of the small intestine. The secretagogues (agents that cause or stimulate secretion) of this hormone include major nutrients like carbohydrate, protein and lipid. Once in the circulation, GLP-1 has a half-life of less than 2 minutes, due to rapid degradation by the enzyme dipeptidyl peptidase-4. It is a potent antihyperglycemic hormone, inducing glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Such glucose-dependent action is particularly attractive because, when the plasma glucose concentration is in the normal fasting range, GLP-1 no longer stimulates insulin to cause hypoglycemia. GLP-1 appears to restore the glucose sensitivity of pancreatic β-cells, with the mechanism possibly involving the increased expression of GLUT2 and glucokinase. GLP-1 is also known to inhibit pancreatic β-cell apoptosis and stimulate the proliferation and differentiation of insulin-secreting β-cells. In addition, GLP-1 inhibits gastric secretion and motility. This delays and protracts carbohydrate absorption and contributes to a satiating effect.".
- Q424611 thumbnail Incretins_and_DPP_4_inhibitors.svg?width=300.
- Q424611 wikiPageExternalLink 8.full.
- Q424611 wikiPageExternalLink show_pathway?ko04911+K04581.
- Q424611 wikiPageWikiLink Q1029907.
- Q424611 wikiPageWikiLink Q11358.
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- Q424611 wikiPageWikiLink Q14863077.
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- Q424611 wikiPageWikiLink Q1500732.
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- Q424611 wikiPageWikiLink Q21163221.
- Q424611 wikiPageWikiLink Q2526479.
- Q424611 wikiPageWikiLink Q26972.
- Q424611 wikiPageWikiLink Q2995031.
- Q424611 wikiPageWikiLink Q3025883.
- Q424611 wikiPageWikiLink Q3510429.
- Q424611 wikiPageWikiLink Q37525.
- Q424611 wikiPageWikiLink Q38173.
- Q424611 wikiPageWikiLink Q417762.
- Q424611 wikiPageWikiLink Q419770.
- Q424611 wikiPageWikiLink Q419832.
- Q424611 wikiPageWikiLink Q419968.
- Q424611 wikiPageWikiLink Q419977.
- Q424611 wikiPageWikiLink Q47273.
- Q424611 wikiPageWikiLink Q48360.
- Q424611 wikiPageWikiLink Q5380231.
- Q424611 wikiPageWikiLink Q5572286.
- Q424611 wikiPageWikiLink Q5572288.
- Q424611 wikiPageWikiLink Q6431240.
- Q424611 wikiPageWikiLink Q7214357.
- Q424611 wikiPageWikiLink Q7248360.
- Q424611 wikiPageWikiLink Q7403984.
- Q424611 wikiPageWikiLink Q8054.
- Q424611 wikiPageWikiLink Q8255706.
- Q424611 wikiPageWikiLink Q898362.
- Q424611 wikiPageWikiLink Q9618.
- Q424611 comment "Glucagon-like peptide-1 (GLP-1) is a neuropeptide and an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the periphery is the intestinal L cell that secretes GLP-1 as a gut hormone; the major source in the brain is the nucleus of the solitary tract, which is the source of a widely distributed set of GLP-1 projection neurons. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2.".
- Q424611 label "Glucagon-like peptide-1".
- Q424611 depiction Incretins_and_DPP_4_inhibitors.svg.