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- Q423624 subject Q7158363.
- Q423624 subject Q8590829.
- Q423624 abstract "Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. It has two parts, paramagnetic manganese (II) ions and the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue. The manganese shortens the longitudinal relaxation time (T1), making the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified.Teslascan was withdrawn from the US market in 2003 and the European market in 2012.Reactive oxygen species (ROS) and reactive nitrogen species (RNS) participate in pathological tissue damage. Mitochondrial manganese superoxide dismutase (MnSOD) normally keeps ROS and RNS in check. During development of mangafodipir as an MRI contrast agent, it was discovered that it possessed MnSOD mimetic activity. Mangafodipir has been tested as a chemotherapy adjunct in cancer patients and as an adjunct to percutaneous coronary intervention in patients with myocardial infarctions, with promising results. Whereas MRI contrast depends on release of Mn2+, the MnSOD mimetic activity depends on Mn2+ that remains bound to DPDP. Calmangafodipir [Ca4Mn(DPDP)5] (brand name PledOx) is stabilized with respect to Mn2+ and has improved therapeutic activity. Calmangafodipir is being explored as a chemotherapy adjunct in cancer patients.".
- Q423624 atcPrefix "V08".
- Q423624 atcSuffix "CA05".
- Q423624 casNumber "119797-12-5".
- Q423624 fdaUniiCode "N02W67RKJS".
- Q423624 pubchem "3086672".
- Q423624 thumbnail Mangafodipir_3D_sticks.png?width=300.
- Q423624 wikiPageExternalLink Teslascaninj.htm.
- Q423624 wikiPageExternalLink 203456.html.
- Q423624 wikiPageExternalLink www.teslascan.com.
- Q423624 wikiPageWikiLink Q161238.
- Q423624 wikiPageWikiLink Q188479.
- Q423624 wikiPageWikiLink Q319827.
- Q423624 wikiPageWikiLink Q640448.
- Q423624 wikiPageWikiLink Q6849688.
- Q423624 wikiPageWikiLink Q7158363.
- Q423624 wikiPageWikiLink Q8590829.
- Q423624 wikiPageWikiLink Q900475.
- Q423624 wikiPageWikiLink Q9377.
- Q423624 atcPrefix "V08".
- Q423624 atcSuffix "CA05".
- Q423624 casNumber "119797".
- Q423624 pubchem "3086672".
- Q423624 unii "N02W67RKJS".
- Q423624 type ChemicalSubstance.
- Q423624 type Drug.
- Q423624 type ChemicalObject.
- Q423624 type Thing.
- Q423624 type Q8386.
- Q423624 comment "Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. It has two parts, paramagnetic manganese (II) ions and the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue.".
- Q423624 label "Mangafodipir".
- Q423624 depiction Mangafodipir_3D_sticks.png.