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- Q422229 subject Q7486806.
- Q422229 subject Q8297721.
- Q422229 subject Q8918235.
- Q422229 subject Q8949762.
- Q422229 subject Q8965786.
- Q422229 abstract "Diltiazem (INN) (/dɪlˈtaɪəzɛm/) is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which opens (dilates) the arteries, allows blood to flow more easily, and lowers blood pressure. Additionally, it lowers blood pressure by acting on the heart itself to reduce the rate, strength, and conduction speed of each beat.It is also used off-label as an effective preventive medication for migraine. It is a class 3 antianginal drug, and a class IV antiarrhythmic. It is a common adulterant of cocaine seized in the UK, and has been found to reduce cocaine cravings in rats, indicating it may prolong the "high" (see below). Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme which can cause it to interact with a variety of other medications.".
- Q422229 atcPrefix "C05".
- Q422229 atcSuffix "AE03".
- Q422229 bioavailability "40.0".
- Q422229 casNumber "42399-41-7".
- Q422229 chEBI "101278".
- Q422229 drugbank "DB00343".
- Q422229 fdaUniiCode "EE92BBP03H".
- Q422229 iupacName "cis-(+)-[2-(2-Dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate".
- Q422229 pubchem "39186".
- Q422229 thumbnail Diltiazem_structure.svg?width=300.
- Q422229 wikiPageExternalLink dpdirect.jsp?name=Diltiazem.
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- Q422229 wikiPageWikiLink Q7486806.
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- Q422229 wikiPageWikiLink Q8297721.
- Q422229 wikiPageWikiLink Q8918235.
- Q422229 wikiPageWikiLink Q8949762.
- Q422229 wikiPageWikiLink Q8965786.
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- Q422229 atcPrefix "5.0".
- Q422229 atcSuffix "AE03".
- Q422229 bioavailability "40.0".
- Q422229 casNumber "42399".
- Q422229 chebi "101278".
- Q422229 drugbank "DB00343".
- Q422229 iupacName "cis--[2--5--3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate".
- Q422229 pubchem "39186".
- Q422229 unii "EE92BBP03H".
- Q422229 type ChemicalSubstance.
- Q422229 type Drug.
- Q422229 type ChemicalObject.
- Q422229 type Thing.
- Q422229 type Q8386.
- Q422229 comment "Diltiazem (INN) (/dɪlˈtaɪəzɛm/) is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which opens (dilates) the arteries, allows blood to flow more easily, and lowers blood pressure.".
- Q422229 label "Diltiazem".
- Q422229 depiction Diltiazem_structure.svg.