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- Q421614 subject Q15202753.
- Q421614 subject Q52305.
- Q421614 subject Q52309.
- Q421614 subject Q8341873.
- Q421614 subject Q8461226.
- Q421614 subject Q8732905.
- Q421614 abstract "Caryophyllene /ˌkærioʊfɪˈliːn/, or (−)-β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (cloves), the essential oil of hemp Cannabis sativa, rosemary Rosmarinus officinalis, and hops. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and α-humulene (obsolete name: α-caryophyllene), a ring-opened isomer. Caryophyllene is notable for having a cyclobutane ring, a rarity in nature.Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. Beta-caryophyllene was shown to be selective agonist of cannabinoid receptor type-2 (CB2) and to exert significant cannabimimetic antiinflammatory effects in mice. Antinociceptive, neuroprotective, anxiolytic and antidepressant and anti-alcoholism activity have been uncovered. Because the widespread plant natural product beta-caryophyllene is an FDA approved food additive and ingested daily with food it is the first dietary cannabinoid. Whether this compound is able to modulate inflammatory processes in humans via the endocannabinoid system is yet unknown. Beta-caryophyllene does not bind to the centrally expressed cannabinoid receptor type-1 (CB1) and therefore does not exert psychotomimetic effects.The first total synthesis of caryophyllene in 1964 by E.J. Corey was considered one of the classic demonstrations of the possibilities of synthetic organic chemistry at the time.Caryophyllene oxide, in which the olefin of caryophyllene has become an epoxide, is the component responsible for cannabis identification by drug-sniffing dogs and is also an approved food flavoring.".
- Q421614 iupacName "4,11,11-trimethyl-8-methylene-".
- Q421614 iupacName "bicyclo[7.2.0]undec-4-ene".
- Q421614 thumbnail Beta-Caryophyllen.svg?width=300.
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- Q421614 wikiPageWikiLink Q8341873.
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- Q421614 iupacname "41111".
- Q421614 iupacname "bicyclo[7.2.0]undec-4-ene".
- Q421614 name "Caryophyllene".
- Q421614 type ChemicalCompound.
- Q421614 type ChemicalSubstance.
- Q421614 type ChemicalObject.
- Q421614 type Thing.
- Q421614 type Q11173.
- Q421614 comment "Caryophyllene /ˌkærioʊfɪˈliːn/, or (−)-β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (cloves), the essential oil of hemp Cannabis sativa, rosemary Rosmarinus officinalis, and hops. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and α-humulene (obsolete name: α-caryophyllene), a ring-opened isomer.".
- Q421614 label "Caryophyllene".
- Q421614 depiction Beta-Caryophyllen.svg.
- Q421614 name "Caryophyllene".