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- Q4215980 abstract "Raji cell line is the first continuous human cell line from hematopoietic origin. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis. Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed. Raji cell is widely used as a transfection host and also to understand the hematopoietic and other cell malignancies. It also use for detection of immune complex because it possesses and expresses and lots of receptors for certain complement components, as well as Fc receptors for immunoglobulin G.".
- Q4215980 thumbnail Raji_cell_lines.jpg?width=300.
- Q4215980 wikiPageExternalLink CVCL_0511.
- Q4215980 wikiPageWikiLink Q1016605.
- Q4215980 wikiPageWikiLink Q110084.
- Q4215980 wikiPageWikiLink Q12078.
- Q4215980 wikiPageWikiLink Q1429031.
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- Q4215980 wikiPageWikiLink Q1663763.
- Q4215980 wikiPageWikiLink Q1873857.
- Q4215980 wikiPageWikiLink Q19596213.
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- Q4215980 wikiPageWikiLink Q5008164.
- Q4215980 wikiPageWikiLink Q5520338.
- Q4215980 wikiPageWikiLink Q575241.
- Q4215980 wikiPageWikiLink Q6005374.
- Q4215980 wikiPageWikiLink Q644318.
- Q4215980 wikiPageWikiLink Q6853.
- Q4215980 wikiPageWikiLink Q6900.
- Q4215980 wikiPageWikiLink Q715347.
- Q4215980 wikiPageWikiLink Q79448.
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- Q4215980 wikiPageWikiLink Q79460.
- Q4215980 wikiPageWikiLink Q79899.
- Q4215980 wikiPageWikiLink Q919283.
- Q4215980 comment "Raji cell line is the first continuous human cell line from hematopoietic origin. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells.".
- Q4215980 label "Raji cell".
- Q4215980 depiction Raji_cell_lines.jpg.