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- Q4198767 subject Q9245110.
- Q4198767 abstract "The isoprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidationof essential fatty acids (primarily arachidonic acid) without the direct action of cyclooxygenase (COX) enzymes. The compounds were discovered in 1990 by L. Jackson Roberts and Jason D. Morrow in the Division of Clinical Pharmacology at Vanderbilt University.These nonclassical eicosanoids possess potent biological activity as inflammatory mediators that augment the perception of pain. These compounds are accurate markers of lipid peroxidation in both animal and human models of oxidative stress.Elevated levels of isoprostanes are suspected of contributing to increased risk of heart attack in patients taking Coxibs. Isoprostanes and their metabolites have also been shown to be elevated in the urine of cigarette smokers, and have been suggested as biomarkers of oxidative stress in smokers.".
- Q4198767 wikiPageWikiLink Q101991.
- Q4198767 wikiPageWikiLink Q209717.
- Q4198767 wikiPageWikiLink Q377458.
- Q4198767 wikiPageWikiLink Q378154.
- Q4198767 wikiPageWikiLink Q407699.
- Q4198767 wikiPageWikiLink Q409990.
- Q4198767 wikiPageWikiLink Q410251.
- Q4198767 wikiPageWikiLink Q423345.
- Q4198767 wikiPageWikiLink Q7049212.
- Q4198767 wikiPageWikiLink Q81938.
- Q4198767 wikiPageWikiLink Q898539.
- Q4198767 wikiPageWikiLink Q898814.
- Q4198767 wikiPageWikiLink Q9245110.
- Q4198767 comment "The isoprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidationof essential fatty acids (primarily arachidonic acid) without the direct action of cyclooxygenase (COX) enzymes. The compounds were discovered in 1990 by L. Jackson Roberts and Jason D. Morrow in the Division of Clinical Pharmacology at Vanderbilt University.These nonclassical eicosanoids possess potent biological activity as inflammatory mediators that augment the perception of pain.".
- Q4198767 label "Isoprostane".