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- Q419750 subject Q9245110.
- Q419750 abstract "Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells. It is critical to development of allergic diseases such as asthma.Research carried out in 1989 found PGD2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid).A 2012 research paper indicates a causal link between elevated levels of localized PGD2 and hair growth inhibition. Applied topically, the researchers found PGD2 prevents hair growth, and mice that were genetically inclined to produce higher levels of PGD2 had inhibited hair growth. The researchers also found PGD2 levels were much higher in balding scalp tissue than nonbalding scalp tissue, through increased levels of prostaglandin D2 synthase. The paper suggested that inhibition of hair growth involved binding of PGD2 to a receptor called GPR44, and that GPR44 therefore would be a therapeutic target for androgenic alopecia in both men and women with hair loss and thinning. Because PGD2's relation to asthma has been known for several years, several drugs that seek to reduce the effect of PGD2 through blocking the GPR44 are already in clinical trials.".
- Q419750 iupacName "9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid".
- Q419750 thumbnail Prostaglandin_D2_structure.png?width=300.
- Q419750 wikiPageWikiLink Q107238.
- Q419750 wikiPageWikiLink Q1073.
- Q419750 wikiPageWikiLink Q107988.
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- Q419750 wikiPageWikiLink Q18031654.
- Q419750 wikiPageWikiLink Q18032412.
- Q419750 wikiPageWikiLink Q18036432.
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- Q419750 wikiPageWikiLink Q186752.
- Q419750 wikiPageWikiLink Q191989.
- Q419750 wikiPageWikiLink Q202771.
- Q419750 wikiPageWikiLink Q209717.
- Q419750 wikiPageWikiLink Q2276095.
- Q419750 wikiPageWikiLink Q35869.
- Q419750 wikiPageWikiLink Q407699.
- Q419750 wikiPageWikiLink Q416554.
- Q419750 wikiPageWikiLink Q416567.
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- Q419750 wikiPageWikiLink Q49117.
- Q419750 wikiPageWikiLink Q507443.
- Q419750 wikiPageWikiLink Q632518.
- Q419750 wikiPageWikiLink Q8047.
- Q419750 wikiPageWikiLink Q866324.
- Q419750 wikiPageWikiLink Q904407.
- Q419750 wikiPageWikiLink Q9245110.
- Q419750 wikiPageWikiLink Q9622.
- Q419750 iupacname "9".
- Q419750 type ChemicalCompound.
- Q419750 type ChemicalSubstance.
- Q419750 type ChemicalObject.
- Q419750 type Thing.
- Q419750 type Q11173.
- Q419750 comment "Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells.".
- Q419750 label "Prostaglandin D2".
- Q419750 depiction Prostaglandin_D2_structure.png.