Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q417909> ?p ?o }
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- Q417909 subject Q5920511.
- Q417909 subject Q6900265.
- Q417909 subject Q7145095.
- Q417909 subject Q7334131.
- Q417909 subject Q8167983.
- Q417909 subject Q8503308.
- Q417909 subject Q9546190.
- Q417909 abstract "Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from markets worldwide.Terfenadine is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme Cytochrome P450 3A4Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is not measurable in the plasma. Terfenadine itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. Terfenadine, in addition to its antihistamine effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity is associated with fexofenadine. Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods such as grapefruit. The addition of, or dosage change in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine. In larger plasma concentrations, it may lead to toxic effects on the heart's rhythm (e.g. ventricular tachycardia and torsades de pointes).".
- Q417909 atcPrefix "R06".
- Q417909 atcSuffix "AX12".
- Q417909 casNumber "50679-08-8".
- Q417909 drugbank "DB00342".
- Q417909 fdaUniiCode "7BA5G9Y06Q".
- Q417909 iupacName "(RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol".
- Q417909 pubchem "5405".
- Q417909 thumbnail Terfenadine.svg?width=300.
- Q417909 wikiPageExternalLink 800A.htm.
- Q417909 wikiPageWikiLink Q12074763.
- Q417909 wikiPageWikiLink Q1475848.
- Q417909 wikiPageWikiLink Q14864419.
- Q417909 wikiPageWikiLink Q14865830.
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- Q417909 wikiPageWikiLink Q204711.
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- Q417909 wikiPageWikiLink Q2327739.
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- Q417909 wikiPageWikiLink Q272436.
- Q417909 wikiPageWikiLink Q324089.
- Q417909 wikiPageWikiLink Q407883.
- Q417909 wikiPageWikiLink Q415122.
- Q417909 wikiPageWikiLink Q422687.
- Q417909 wikiPageWikiLink Q42982.
- Q417909 wikiPageWikiLink Q467717.
- Q417909 wikiPageWikiLink Q4832014.
- Q417909 wikiPageWikiLink Q542511.
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- Q417909 wikiPageWikiLink Q5920511.
- Q417909 wikiPageWikiLink Q603741.
- Q417909 wikiPageWikiLink Q6900265.
- Q417909 wikiPageWikiLink Q7145095.
- Q417909 wikiPageWikiLink Q7334131.
- Q417909 wikiPageWikiLink Q7707111.
- Q417909 wikiPageWikiLink Q8167983.
- Q417909 wikiPageWikiLink Q8503308.
- Q417909 wikiPageWikiLink Q879952.
- Q417909 wikiPageWikiLink Q9546190.
- Q417909 atcPrefix "R06".
- Q417909 atcSuffix "AX12".
- Q417909 casNumber "50679".
- Q417909 drugbank "DB00342".
- Q417909 iupacName "-1".
- Q417909 pubchem "5405".
- Q417909 unii "7".
- Q417909 type ChemicalSubstance.
- Q417909 type Drug.
- Q417909 type ChemicalObject.
- Q417909 type Thing.
- Q417909 type Q8386.
- Q417909 comment "Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia.".
- Q417909 label "Terfenadine".
- Q417909 depiction Terfenadine.svg.