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- Q416602 subject Q15258842.
- Q416602 subject Q20740287.
- Q416602 subject Q8417141.
- Q416602 subject Q8420862.
- Q416602 subject Q8579838.
- Q416602 abstract "Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound, first isolated by Pierre Boullay in 1812. The name "picrotoxin" is a combination of the Greek words "picros" (bitter) and "toxicon" (poison).Found primarily in the fruit of the climbing plant Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive channel blocker for the GABAA receptor chloride channels. It is therefore a channel blocker rather than a receptor antagonist.On the other hand, evidence exists that picrotoxin acts as a competitive antagonist, and not as a channel blocker. For example, Newland and Cull-Candy (1992) found that when recording GABA-activated currents in neurons, picrotoxin "did not alter the amplitude of the main conductance state. However, picrotoxin did reduce the frequency of channel openings." They concluded, "Our data are consistent with a mechanism whereby picrotoxin binds preferentially to an agonist bound form of the receptor and stabilizes an agonist-bound shut state. This could, for example, mean that picrotoxin enhances the occurrence of a desensitized state or an allosterically blocked state." As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has stimulant and convulsant effects. As such, picrotoxin can be used to counter barbiturate poisoning, that can occur during general anesthesia or during a large intake outside of the hospital.".
- Q416602 atcPrefix "none".
- Q416602 casNumber "124-87-8".
- Q416602 drugbank "DB00466".
- Q416602 fdaUniiCode "ZLT174DL7U".
- Q416602 pubchem "5360688".
- Q416602 thumbnail Picrotoxin_3D_sticks.png?width=300.
- Q416602 wikiPageExternalLink bv.fcgi?rid=bnchm.section.1181.
- Q416602 wikiPageExternalLink 00016488209130882.
- Q416602 wikiPageWikiLink Q15258842.
- Q416602 wikiPageWikiLink Q2007832.
- Q416602 wikiPageWikiLink Q206348.
- Q416602 wikiPageWikiLink Q20740287.
- Q416602 wikiPageWikiLink Q41509.
- Q416602 wikiPageWikiLink Q466561.
- Q416602 wikiPageWikiLink Q5072487.
- Q416602 wikiPageWikiLink Q60147.
- Q416602 wikiPageWikiLink Q8417141.
- Q416602 wikiPageWikiLink Q8420862.
- Q416602 wikiPageWikiLink Q8579838.
- Q416602 atcPrefix "none".
- Q416602 casNumber "124".
- Q416602 drugbank "DB00466".
- Q416602 pubchem "5360688".
- Q416602 unii "ZLT174DL7U".
- Q416602 type ChemicalSubstance.
- Q416602 type Drug.
- Q416602 type ChemicalObject.
- Q416602 type Thing.
- Q416602 type Q8386.
- Q416602 comment "Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound, first isolated by Pierre Boullay in 1812. The name "picrotoxin" is a combination of the Greek words "picros" (bitter) and "toxicon" (poison).Found primarily in the fruit of the climbing plant Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive channel blocker for the GABAA receptor chloride channels.".
- Q416602 label "Picrotoxin".
- Q416602 depiction Picrotoxin_3D_sticks.png.