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- Q414745 subject Q8493059.
- Q414745 abstract "Buserelin (INN) is a gonadotropin-releasing hormone agonist (GnRH agonist). The drug's effects are dependent on the frequency and time course of administration. GnRH is released in a pulsatile fashion in the postpubertal adult. Initial interaction of any GnRH agonist, such as buserelin, with the GnRH receptor induces release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by gonadotrophes. Long-term exposure to constant levels of buserelin, rather than endogenous pulses, leads to downregulation of the GnRH receptors and subsequent suppression of the pituitary release of LH and FSH.Like other GnRH agonists, buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.It is normally delivered via a nasal spray, but is also available as an injection.Buserelin acetate is marketed by Sanofi-Aventis under the brand name Suprefact and a generic form of buserelin is now produced by CinnaGen under the brand name CinnaFact.Buserelin is also marketed under the brand name Metrelef. Metrelef is approved to treat patients with endometriosis by suppression of ovarian hormone production. In ovulation induction It is used as a pituitary blockade as an adjunct to gonadotrophin administration.".
- Q414745 atcPrefix "L02".
- Q414745 atcSuffix "AE01".
- Q414745 casNumber "57982-77-1".
- Q414745 drugbank "DB06719".
- Q414745 fdaUniiCode "PXW8U3YXDV".
- Q414745 pubchem "50225".
- Q414745 thumbnail Buserelin.svg?width=300.
- Q414745 wikiPageWikiLink Q128581.
- Q414745 wikiPageWikiLink Q1318776.
- Q414745 wikiPageWikiLink Q1366695.
- Q414745 wikiPageWikiLink Q14864006.
- Q414745 wikiPageWikiLink Q156871.
- Q414745 wikiPageWikiLink Q158205.
- Q414745 wikiPageWikiLink Q1755275.
- Q414745 wikiPageWikiLink Q178066.
- Q414745 wikiPageWikiLink Q181257.
- Q414745 wikiPageWikiLink Q184674.
- Q414745 wikiPageWikiLink Q1858291.
- Q414745 wikiPageWikiLink Q200774.
- Q414745 wikiPageWikiLink Q205764.
- Q414745 wikiPageWikiLink Q208360.
- Q414745 wikiPageWikiLink Q3606696.
- Q414745 wikiPageWikiLink Q409770.
- Q414745 wikiPageWikiLink Q486975.
- Q414745 wikiPageWikiLink Q5121014.
- Q414745 wikiPageWikiLink Q556281.
- Q414745 wikiPageWikiLink Q7314318.
- Q414745 wikiPageWikiLink Q824258.
- Q414745 wikiPageWikiLink Q8493059.
- Q414745 wikiPageWikiLink Q907160.
- Q414745 wikiPageWikiLink Q9377.
- Q414745 atcPrefix "L02".
- Q414745 atcSuffix "AE01".
- Q414745 casNumber "57982".
- Q414745 drugbank "DB06719".
- Q414745 pubchem "50225".
- Q414745 unii "PXW8U3YXDV".
- Q414745 type ChemicalSubstance.
- Q414745 type Drug.
- Q414745 type ChemicalObject.
- Q414745 type Thing.
- Q414745 type Q8386.
- Q414745 comment "Buserelin (INN) is a gonadotropin-releasing hormone agonist (GnRH agonist). The drug's effects are dependent on the frequency and time course of administration. GnRH is released in a pulsatile fashion in the postpubertal adult. Initial interaction of any GnRH agonist, such as buserelin, with the GnRH receptor induces release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by gonadotrophes.".
- Q414745 label "Buserelin".
- Q414745 depiction Buserelin.svg.