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- Q414463 subject Q7139608.
- Q414463 subject Q8645495.
- Q414463 subject Q8887197.
- Q414463 subject Q9516482.
- Q414463 abstract "Tapentadol (brand names: Nucynta, Palexia and Tapal) is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Its analgesic properties come into effect within thirty-two minutes of oral administration, and last for 4–6 hours.It is similar to tramadol in its dual mechanism of action; namely, its ability to activate the mu opioid receptor and inhibit the reuptake of norepinephrine. Unlike tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites. Unlike most other opiates of similar potency (ex. tramadol, oxycodone, hydrocodone, codeine), tapentadol is not a pro-drug and therefor does not rely on metabolism to produce its therapeutic effects; this makes it a useful moderate-potency analgesic option for patients who do not respond adequately to more commonly used opiates due to genetic disposition (poor metabolizers of CYP3A4 and CYP2D6), as well as providing a more consistent dosage-response range among the patient population.Its general potency is somewhere between that of tramadol and morphine, with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects. As such, it is generally regarded as a weak-moderate strength opioid.It was approved by the US FDA on the 20th of November, 2008, by the MHRA of the UK on the 4th of February 2011 and by the TGA of Australia on the 24th of December 2010.".
- Q414463 atcPrefix "N02".
- Q414463 atcSuffix "AX06".
- Q414463 bioavailability "32.0".
- Q414463 casNumber "175591-09-0".
- Q414463 fdaUniiCode "H8A007M585".
- Q414463 iupacName "3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-".
- Q414463 iupacName "methylpropyl]phenol hydrochloride".
- Q414463 pubchem "9838022".
- Q414463 thumbnail Tapentadol.svg?width=300.
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- Q414463 atcPrefix "N02".
- Q414463 atcSuffix "AX06".
- Q414463 bioavailability "32.0".
- Q414463 casNumber "175591".
- Q414463 iupacName "3".
- Q414463 iupacName "methylpropyl]phenol hydrochloride".
- Q414463 pubchem "9838022".
- Q414463 unii "H8A007M585".
- Q414463 type ChemicalSubstance.
- Q414463 type Drug.
- Q414463 type ChemicalObject.
- Q414463 type Thing.
- Q414463 type Q8386.
- Q414463 comment "Tapentadol (brand names: Nucynta, Palexia and Tapal) is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI).".
- Q414463 label "Tapentadol".
- Q414463 depiction Tapentadol.svg.