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- Q4052540 subject Q8549984.
- Q4052540 abstract "Integrin alpha4beta1 (Very Late Antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1).Vascular cell adhesion molecule-1 (VCAM-1 - an integrin receptor) located on an endothelial cell, binds to the integrin VLA-4 which are normally expressed on leukocyte plasma membranes, but they do not adhere to their appropriate ligands until the leukocytes are activated by chemotactic agents or other stimuli (often produced by the endothelium or other cells at the site of injury). Only then do the integrins undergo the conformational change necessary to confer high binding affinity for the endothelial adhesion molecules.In multiple sclerosis, the VLA-4 integrin is essential in the processes by which T-cells gain access to the brain by allowing the cells to penetrate the blood brain barrier that normally restricts immune cell access. One approach to prevent an autoimmune reaction has been to block the action of VLA-4 so that self-reactive T-cells are unable to enter the brain and thus unable to attack myelin protein.In recent years antagonists of VLA-4 have shown great promise in treating inflammatory disorders in a number of animal models. However, the usage of Natalizumab, an antagonist of VLA-4 integrin, remains controversial due to several side effects including Progressive multifocal leukoencephalopathy.".
- Q4052540 wikiPageExternalLink report.cgi?report=compl_overview&compl_acc=cc00000018.
- Q4052540 wikiPageExternalLink index.shtml.
- Q4052540 wikiPageWikiLink Q14901827.
- Q4052540 wikiPageWikiLink Q14912083.
- Q4052540 wikiPageWikiLink Q14912099.
- Q4052540 wikiPageWikiLink Q193161.
- Q4052540 wikiPageWikiLink Q193529.
- Q4052540 wikiPageWikiLink Q221694.
- Q4052540 wikiPageWikiLink Q386119.
- Q4052540 wikiPageWikiLink Q409715.
- Q4052540 wikiPageWikiLink Q42395.
- Q4052540 wikiPageWikiLink Q6589727.
- Q4052540 wikiPageWikiLink Q704930.
- Q4052540 wikiPageWikiLink Q8084905.
- Q4052540 wikiPageWikiLink Q8277.
- Q4052540 wikiPageWikiLink Q8549984.
- Q4052540 comment "Integrin alpha4beta1 (Very Late Antigen-4) is an integrin dimer.".
- Q4052540 label "VLA-4".