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- Q4043340 subject Q6745718.
- Q4043340 subject Q8343806.
- Q4043340 abstract "M1G (pyrimido[1,2-a]purin-10(3H)-one) is a heterocyclic compound which is a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG. The M1dG adduct in turn is formed by a condensation reaction between guanosine nucleotides in DNA and either malondialdehyde (propanedial) or acrolein. If not repaired, these adducts are mutagenic and carcinogenic.Malondialdehyde is an end product of lipid peroxidation while acrolein is a result of DNA peroxidation.M1dG is the major endogenous DNA adduct in humans. M1dG adducts have been detected in cell DNA in liver, leucocytes, pancreas and breast in concentrations of 1-120 per 108 nucleotides. Detection and quantification of M1dG adducts in the body as measured by free M1G is a tool for detecting DNA damage that may lead to cancer. Free M1G is also biomarker for oxidative stress.".
- Q4043340 iupacName "pyrimido[1,2-a]purin-10(3H)-one".
- Q4043340 thumbnail M1G_V2.png?width=300.
- Q4043340 wikiPageWikiLink Q1128255.
- Q4043340 wikiPageWikiLink Q187661.
- Q4043340 wikiPageWikiLink Q193430.
- Q4043340 wikiPageWikiLink Q221696.
- Q4043340 wikiPageWikiLink Q285982.
- Q4043340 wikiPageWikiLink Q28745.
- Q4043340 wikiPageWikiLink Q3113091.
- Q4043340 wikiPageWikiLink Q342790.
- Q4043340 wikiPageWikiLink Q4153410.
- Q4043340 wikiPageWikiLink Q418661.
- Q4043340 wikiPageWikiLink Q422462.
- Q4043340 wikiPageWikiLink Q42395.
- Q4043340 wikiPageWikiLink Q6745718.
- Q4043340 wikiPageWikiLink Q8343806.
- Q4043340 wikiPageWikiLink Q864574.
- Q4043340 wikiPageWikiLink Q898539.
- Q4043340 wikiPageWikiLink Q898814.
- Q4043340 wikiPageWikiLink Q910058.
- Q4043340 wikiPageWikiLink Q9103.
- Q4043340 wikiPageWikiLink Q9368.
- Q4043340 wikiPageWikiLink Q9618.
- Q4043340 iupacname "pyrimido[1,2-a]purin-10-one".
- Q4043340 type ChemicalCompound.
- Q4043340 type ChemicalSubstance.
- Q4043340 type ChemicalObject.
- Q4043340 type Thing.
- Q4043340 type Q11173.
- Q4043340 comment "M1G (pyrimido[1,2-a]purin-10(3H)-one) is a heterocyclic compound which is a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG. The M1dG adduct in turn is formed by a condensation reaction between guanosine nucleotides in DNA and either malondialdehyde (propanedial) or acrolein.".
- Q4043340 label "M1G".
- Q4043340 depiction M1G_V2.png.