Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q402093> ?p ?o }
Showing triples 1 to 44 of
44
with 100 triples per page.
- Q402093 subject Q16812560.
- Q402093 subject Q7213749.
- Q402093 subject Q7217197.
- Q402093 abstract "Reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development. After fertilization some cells of the newly formed embryo migrate to the germinal ridge and will eventually become the germ cells (sperm and oocytes). Due to the phenomenon of genomic imprinting, maternal and paternal genomes are differentially marked and must be properly reprogrammed every time they pass through the germline. Therefore, during the process of gametogenesis the primordial germ cells must have their original biparental DNA methylation patterns erased and re-established based on the sex of the transmitting parent.After fertilization the paternal and maternal genomes are once again demethylated and remethylated (except for differentially methylated regions associated with imprinted genes). This reprogramming is likely required for totipotency of the newly formed embryo and erasure of acquired epigenetic changes. In vitro manipulation of pre-implantation embryos has been shown to disrupt methylation patterns at imprinted loci and plays a crucial role in cloned animals.Reprogramming can also be induced artificially through the introduction of exogenous factors, usually transcription factors. In this context, it often refers to the creation of induced pluripotent stem cells from mature cells such as adult fibroblasts. This allows the production of stem cells for biomedical research, such as research into stem cell therapies, without the use of embryos. It is carried out by the transfection of stem-cell associated genes into mature cells using viral vectors such as retroviruses.".
- Q402093 wikiPageExternalLink 3.R1.pdf.
- Q402093 wikiPageExternalLink S0047-6374(06)00039-X.
- Q402093 wikiPageExternalLink nlm?genre=article&issn=1472-6483&volume=7&issue=6&spage=649&aulast=Wrenzycki.
- Q402093 wikiPageExternalLink pmidlookup?view=long&pmid=12748125.
- Q402093 wikiPageExternalLink pmidlookup?view=long&pmid=11498579.
- Q402093 wikiPageWikiLink Q120877.
- Q402093 wikiPageWikiLink Q1353638.
- Q402093 wikiPageWikiLink Q1410510.
- Q402093 wikiPageWikiLink Q1429031.
- Q402093 wikiPageWikiLink Q14864661.
- Q402093 wikiPageWikiLink Q15107837.
- Q402093 wikiPageWikiLink Q1533033.
- Q402093 wikiPageWikiLink Q16812560.
- Q402093 wikiPageWikiLink Q171433.
- Q402093 wikiPageWikiLink Q18031649.
- Q402093 wikiPageWikiLink Q18033993.
- Q402093 wikiPageWikiLink Q189308.
- Q402093 wikiPageWikiLink Q1939923.
- Q402093 wikiPageWikiLink Q20969939.
- Q402093 wikiPageWikiLink Q2298489.
- Q402093 wikiPageWikiLink Q2752427.
- Q402093 wikiPageWikiLink Q281579.
- Q402093 wikiPageWikiLink Q3246226.
- Q402093 wikiPageWikiLink Q407384.
- Q402093 wikiPageWikiLink Q44335.
- Q402093 wikiPageWikiLink Q463418.
- Q402093 wikiPageWikiLink Q48196.
- Q402093 wikiPageWikiLink Q674925.
- Q402093 wikiPageWikiLink Q7191.
- Q402093 wikiPageWikiLink Q7213749.
- Q402093 wikiPageWikiLink Q7217197.
- Q402093 wikiPageWikiLink Q7559240.
- Q402093 wikiPageWikiLink Q80006.
- Q402093 wikiPageWikiLink Q80917.
- Q402093 wikiPageWikiLink Q81218.
- Q402093 wikiPageWikiLink Q84087.
- Q402093 wikiPageWikiLink Q862600.
- Q402093 wikiPageWikiLink Q874745.
- Q402093 comment "Reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development. After fertilization some cells of the newly formed embryo migrate to the germinal ridge and will eventually become the germ cells (sperm and oocytes). Due to the phenomenon of genomic imprinting, maternal and paternal genomes are differentially marked and must be properly reprogrammed every time they pass through the germline.".
- Q402093 label "Reprogramming".