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- Q3634466 subject Q15305141.
- Q3634466 subject Q7369691.
- Q3634466 abstract "Bapineuzumab (nicknamed "bapi") is a humanized monoclonal antibody that acts on the nervous system and may have potential therapeutic value for the treatment of Alzheimer's disease and possibly glaucoma. However, in 2012 it failed to produce significant cognitive improvements in patients in two major trials, despite lowering key biomarkers of AD, amyloid brain plaque and phosphorylated Tau protein in CSF.Bapineuzumab has been shown to recognise the extreme N-terminal 5 residues of Aβ peptide in a helical conformation (4HIX.pdb) stabilized by internal hydrogen bonds involving the first three amino acids.Bapineuzumab is an antibody to the beta-amyloid (Aβ) plaques that are believed to underlie Alzheimer's disease neuropathology. In previous clinical trials for vaccination against human beta amyloid, called AN-1792, patients with Alzheimer's disease using active immunization had positive outcomes with removal of plaques, but 6% of subjects developed aseptic meningitis and the trial was stopped.".
- Q3634466 atcPrefix "none".
- Q3634466 casNumber "648895-38-9".
- Q3634466 fdaUniiCode "NC11WKO35D".
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- Q3634466 wikiPageWikiLink Q15305141.
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- Q3634466 wikiPageWikiLink Q7369691.
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- Q3634466 atcPrefix "none".
- Q3634466 casNumber "648895".
- Q3634466 unii "NC11WKO35D".
- Q3634466 type ChemicalSubstance.
- Q3634466 type Drug.
- Q3634466 type ChemicalObject.
- Q3634466 type Thing.
- Q3634466 type Q8386.
- Q3634466 comment "Bapineuzumab (nicknamed "bapi") is a humanized monoclonal antibody that acts on the nervous system and may have potential therapeutic value for the treatment of Alzheimer's disease and possibly glaucoma.".
- Q3634466 label "Bapineuzumab".