Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q356188> ?p ?o }
Showing triples 1 to 53 of
53
with 100 triples per page.
- Q356188 subject Q9089708.
- Q356188 subject Q9531303.
- Q356188 abstract "ADP Ribosylation Factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. They are the founding members of a growing family that includes Arl (Arf-like), Arp (Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins. Arf proteins cycle between inactive GDP-bound and active GTP-bound forms that bind selectively to effectors. The classical structural GDP/GTP switch is characterised by conformational changes at the so-called switch 1 and switch 2 regions, which bind tightly to the gamma-phosphate of GTP but poorly or not at all to the GDP nucleotide. Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1 and 2 conformational changes, they depart from other small GTP-binding proteins in that they use an additional, unique switch to propagate structural information from one side of the protein to the other.The GDP/GTP structural cycles of human Arf1 and Arf6 feature a unique conformational change that affects the beta2beta3 strands connecting switch 1 and switch 2 (interswitch) and also the amphipathic helical N-terminus. In GDP-bound Arf1 and Arf6, the interswitch is retracted and forms a pocket to which the N-terminal helix binds, the latter serving as a molecular hasp to maintain the inactive conformation. In the GTP-bound form of these proteins, the interswitch undergoes a two-residue register shift that pulls switch 1 and switch 2 up, restoring an active conformation that can bind GTP. In this conformation, the interswitch projects out of the protein and extrudes the N-terminal hasp by occluding its binding pocket.".
- Q356188 symbol "Arf".
- Q356188 thumbnail 1ksg_opm.png?width=300.
- Q356188 wikiPageWikiLink Q1024108.
- Q356188 wikiPageWikiLink Q103135.
- Q356188 wikiPageWikiLink Q14865053.
- Q356188 wikiPageWikiLink Q1542830.
- Q356188 wikiPageWikiLink Q168790.
- Q356188 wikiPageWikiLink Q17831444.
- Q356188 wikiPageWikiLink Q17831452.
- Q356188 wikiPageWikiLink Q17831515.
- Q356188 wikiPageWikiLink Q17831537.
- Q356188 wikiPageWikiLink Q17831577.
- Q356188 wikiPageWikiLink Q17831613.
- Q356188 wikiPageWikiLink Q17831987.
- Q356188 wikiPageWikiLink Q17831995.
- Q356188 wikiPageWikiLink Q17831998.
- Q356188 wikiPageWikiLink Q18035047.
- Q356188 wikiPageWikiLink Q18035062.
- Q356188 wikiPageWikiLink Q18040027.
- Q356188 wikiPageWikiLink Q18041137.
- Q356188 wikiPageWikiLink Q18041652.
- Q356188 wikiPageWikiLink Q18047405.
- Q356188 wikiPageWikiLink Q18049176.
- Q356188 wikiPageWikiLink Q18049841.
- Q356188 wikiPageWikiLink Q18053190.
- Q356188 wikiPageWikiLink Q185269.
- Q356188 wikiPageWikiLink Q189206.
- Q356188 wikiPageWikiLink Q19088.
- Q356188 wikiPageWikiLink Q25794.
- Q356188 wikiPageWikiLink Q284398.
- Q356188 wikiPageWikiLink Q392227.
- Q356188 wikiPageWikiLink Q407438.
- Q356188 wikiPageWikiLink Q408592.
- Q356188 wikiPageWikiLink Q422582.
- Q356188 wikiPageWikiLink Q423279.
- Q356188 wikiPageWikiLink Q424304.
- Q356188 wikiPageWikiLink Q483261.
- Q356188 wikiPageWikiLink Q7294687.
- Q356188 wikiPageWikiLink Q901088.
- Q356188 wikiPageWikiLink Q9089708.
- Q356188 wikiPageWikiLink Q9531303.
- Q356188 symbol "Arf".
- Q356188 type Biomolecule.
- Q356188 type Protein.
- Q356188 type Thing.
- Q356188 type Q206229.
- Q356188 type Q8054.
- Q356188 comment "ADP Ribosylation Factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.".
- Q356188 label "ADP ribosylation factor".
- Q356188 depiction 1ksg_opm.png.