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- Q341500 subject Q8659716.
- Q341500 subject Q8965786.
- Q341500 abstract "Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.".
- Q341500 atcPrefix "D05".
- Q341500 atcSuffix "BB02".
- Q341500 bioavailability "60.0".
- Q341500 casNumber "55079-83-9".
- Q341500 chEBI "50173".
- Q341500 drugbank "DB00459".
- Q341500 fdaUniiCode "LCH760E9T7".
- Q341500 iupacName "(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid".
- Q341500 pubchem "5284513".
- Q341500 thumbnail Acitretin2DACS.svg?width=300.
- Q341500 wikiPageWikiLink Q1473931.
- Q341500 wikiPageWikiLink Q179945.
- Q341500 wikiPageWikiLink Q420418.
- Q341500 wikiPageWikiLink Q554297.
- Q341500 wikiPageWikiLink Q659446.
- Q341500 wikiPageWikiLink Q686886.
- Q341500 wikiPageWikiLink Q8659716.
- Q341500 wikiPageWikiLink Q8965786.
- Q341500 atcPrefix "D05".
- Q341500 atcSuffix "BB02".
- Q341500 bioavailability "60.0".
- Q341500 casNumber "55079".
- Q341500 chebi "50173".
- Q341500 drugbank "DB00459".
- Q341500 iupacName "-9".
- Q341500 pubchem "5284513".
- Q341500 unii "LCH760E9T7".
- Q341500 type ChemicalSubstance.
- Q341500 type Drug.
- Q341500 type ChemicalObject.
- Q341500 type Thing.
- Q341500 type Q8386.
- Q341500 comment "Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.".
- Q341500 label "Acitretin".
- Q341500 depiction Acitretin2DACS.svg.