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- Q3323035 subject Q5920511.
- Q3323035 subject Q8300132.
- Q3323035 abstract "Lithocholic acid, also known as 3α-hydroxy-5β-cholan-24-oic acid or LCA, is a bile acid that acts as a detergent to solubilize fats for absorption. Bacterial action in the colon produces LCA from chenodeoxycholic acid by reduction of the hydroxyl functional group at carbon-7 in the "B" ring of the steroid framework.It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.Dietary fiber can bind to lithocholic acid and aid in its excretion in stool; as such, fiber can protect against colon cancer.LCA (and LCA acetate and LCA propionate) can activate the vitamin D receptor without raising calcium levels as much as vitamin D itself.".
- Q3323035 iupacName "(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid".
- Q3323035 thumbnail Lithocholic_acid_acsv.svg?width=300.
- Q3323035 wikiPageWikiLink Q104116.
- Q3323035 wikiPageWikiLink Q11083.
- Q3323035 wikiPageWikiLink Q14904927.
- Q3323035 wikiPageWikiLink Q175621.
- Q3323035 wikiPageWikiLink Q177911.
- Q3323035 wikiPageWikiLink Q215210.
- Q3323035 wikiPageWikiLink Q221681.
- Q3323035 wikiPageWikiLink Q413288.
- Q3323035 wikiPageWikiLink Q419028.
- Q3323035 wikiPageWikiLink Q5920511.
- Q3323035 wikiPageWikiLink Q8300132.
- Q3323035 wikiPageWikiLink Q938205.
- Q3323035 iupacname "-4".
- Q3323035 type ChemicalCompound.
- Q3323035 type ChemicalSubstance.
- Q3323035 type ChemicalObject.
- Q3323035 type Thing.
- Q3323035 type Q11173.
- Q3323035 comment "Lithocholic acid, also known as 3α-hydroxy-5β-cholan-24-oic acid or LCA, is a bile acid that acts as a detergent to solubilize fats for absorption. Bacterial action in the colon produces LCA from chenodeoxycholic acid by reduction of the hydroxyl functional group at carbon-7 in the "B" ring of the steroid framework.It has been implicated in human and experimental animal carcinogenesis.".
- Q3323035 label "Lithocholic acid".
- Q3323035 depiction Lithocholic_acid_acsv.svg.