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- Q3288610 subject Q8529536.
- Q3288610 abstract "2-Hydroxybutyric acid (or alpha-hydroxybutyrate,α-hydroxybutyrate ) is a hydroxybutyric acid with the hydroxyl group on the carbon adjacent to the carboxyl. It is a chiral compound having two enantiomers, D-2-hydroxybutyric acid and L-2-hydroxybutyric acid. 2-Hydroxybutyrate, the conjugate base of 2-hydroxybutyric acid, is produced in mammalian tissues (principally hepatic) that catabolize L-threonine or synthesize glutathione. Oxidative stress or detoxification demands can dramatically increase the rate of hepatic glutathione synthesis. Under such metabolic stress conditions, supplies of L-cysteine for glutathione synthesis become limiting, so homocysteine is diverted from the transmethylation pathway forming methionine into the transsulfuration pathway forming cystathionine. 2-Hydroxybutyrate is released as a byproduct when cystathionine is cleaved to cysteine that is incorporated into glutathione. Chronic shifts in the rate of glutathione synthesis may be reflected by urinary excretion of 2-hydroxybutyrate.α-hydroxybutyrate may be useful as an early indicator of insulin resistance in non-diabetic subjects. Moreover, elevated serum α-hydroxybutyrate predicts worsening glucose tolerance.".
- Q3288610 iupacName "2-Hydroxybutanoic acid".
- Q3288610 thumbnail (RS)-2-Hydroxybutanic_Acid_Structural_Formula_V1.svg?width=300.
- Q3288610 wikiPageWikiLink Q104116.
- Q3288610 wikiPageWikiLink Q1053470.
- Q3288610 wikiPageWikiLink Q116907.
- Q3288610 wikiPageWikiLink Q134856.
- Q3288610 wikiPageWikiLink Q161249.
- Q3288610 wikiPageWikiLink Q161521.
- Q3288610 wikiPageWikiLink Q186474.
- Q3288610 wikiPageWikiLink Q186521.
- Q3288610 wikiPageWikiLink Q192466.
- Q3288610 wikiPageWikiLink Q193213.
- Q3288610 wikiPageWikiLink Q2014867.
- Q3288610 wikiPageWikiLink Q209157.
- Q3288610 wikiPageWikiLink Q214514.
- Q3288610 wikiPageWikiLink Q2661464.
- Q3288610 wikiPageWikiLink Q276622.
- Q3288610 wikiPageWikiLink Q2823214.
- Q3288610 wikiPageWikiLink Q2823220.
- Q3288610 wikiPageWikiLink Q3025883.
- Q3288610 wikiPageWikiLink Q3774783.
- Q3288610 wikiPageWikiLink Q421972.
- Q3288610 wikiPageWikiLink Q422956.
- Q3288610 wikiPageWikiLink Q423225.
- Q3288610 wikiPageWikiLink Q423233.
- Q3288610 wikiPageWikiLink Q494483.
- Q3288610 wikiPageWikiLink Q7835367.
- Q3288610 wikiPageWikiLink Q8529536.
- Q3288610 wikiPageWikiLink Q898814.
- Q3288610 wikiPageWikiLink Q935387.
- Q3288610 iupacname "2".
- Q3288610 type ChemicalCompound.
- Q3288610 type ChemicalSubstance.
- Q3288610 type ChemicalObject.
- Q3288610 type Thing.
- Q3288610 type Q11173.
- Q3288610 comment "2-Hydroxybutyric acid (or alpha-hydroxybutyrate,α-hydroxybutyrate ) is a hydroxybutyric acid with the hydroxyl group on the carbon adjacent to the carboxyl. It is a chiral compound having two enantiomers, D-2-hydroxybutyric acid and L-2-hydroxybutyric acid. 2-Hydroxybutyrate, the conjugate base of 2-hydroxybutyric acid, is produced in mammalian tissues (principally hepatic) that catabolize L-threonine or synthesize glutathione.".
- Q3288610 label "2-Hydroxybutyric acid".
- Q3288610 depiction (RS)-2-Hydroxybutanic_Acid_Structural_Formula_V1.svg.