Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q324076> ?p ?o }
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- Q324076 subject Q16813793.
- Q324076 subject Q8374388.
- Q324076 subject Q8570773.
- Q324076 subject Q8672800.
- Q324076 abstract "Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal. Occasionally, prodynorphin is not fully processed, leading to the release of “big dynorphin.” This 32-amino acid molecule consists of both dynorphin A and dynorphin B.Dynorphin A, dynorphin B, and big dynorphin all contain a high proportion of basic amino acid residues, in particular lysine and arginine (29.4%, 23.1%, and 31.2% basic residues, respectively), as well as many hydrophobic residues (41.2%, 30.8%, and 34.4% hydrophobic residues, respectively). Although dynorphins are found widely distributed in the CNS, they have the highest concentrations in the hypothalamus, medulla, pons, midbrain, and spinal cord. Dynorphins are stored in large (80-120 nm diameter) dense-core vesicles that are considerably larger than vesicles storing neurotransmitters. These large dense-core vesicles differ from small synaptic vesicles in that a more intense and prolonged stimulus is needed to cause the large vesicles to release their contents into the synaptic cleft. Dense-core vesicle storage is characteristic of opioid peptides storage.The first clues to the functionality of dynorphins came from Goldstein et al. in their work with opioid peptides. The group discovered an endogenous opioid peptide in the porcine pituitary that proved difficult to isolate. By sequencing the first 13 amino acids of the peptide, they created a synthetic version of the peptide with a similar potency to the natural peptide. Goldstein et al. applied the synthetic peptide to the guinea ileum longitudinal muscle and found it to be an extraordinarily potent opioid peptide. The peptide was called dynorphin (from the Greek dynamis=power) to describe its potency.Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein-coupled receptor. Two subtypes of KORs have been identified: K1 and K2. Although KOR is the primary receptor for all dynorphins, the peptides do have some affinity for the μ-opioid receptor (MOR), δ-opioid receptor (DOR),and the N-methyl-D-aspartic acid (NMDA)-type glutamate receptor. Different dynorphins show different receptor selectivities and potencies at receptors. Big dynorphin and dynorphin A have the same selectivity for human KOR, but dynorphin A is more selective for KOR over MOR and DOR than is big dynorphin. Big dynorphin is more potent at KORs than is dynorphin A. Both big dynorphin and dynorphin A are more potent and more selective than dynorphin B.".
- Q324076 arm "p".
- Q324076 band "ter".
- Q324076 chromosome "20".
- Q324076 entrezgene "5173".
- Q324076 hgncid "8820".
- Q324076 locusSupplementaryData "-p12.2".
- Q324076 omim "131340".
- Q324076 refseq "NM_024411".
- Q324076 symbol "PDYN".
- Q324076 uniprot "P01213".
- Q324076 wikiPageExternalLink index.html?query=pdyn.
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- Q324076 arm "p".
- Q324076 band "ter".
- Q324076 chromosome "20".
- Q324076 entrezgene "5173".
- Q324076 hgncid "8820".
- Q324076 locussupplementarydata "-p12.2".
- Q324076 name "prodynorphin".
- Q324076 omim "131340".
- Q324076 refseq "NM_024411".
- Q324076 symbol "PDYN".
- Q324076 uniprot "P01213".
- Q324076 type Biomolecule.
- Q324076 type Protein.
- Q324076 type Thing.
- Q324076 type Q206229.
- Q324076 type Q8054.
- Q324076 comment "Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal.".
- Q324076 label "Dynorphin".
- Q324076 name "prodynorphin".