Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q323936> ?p ?o }
- Q323936 subject Q22695562.
- Q323936 subject Q7214529.
- Q323936 subject Q9448303.
- Q323936 abstract "Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.".
- Q323936 thumbnail Gráfica_Km.png?width=300.
- Q323936 wikiPageExternalLink adapt.
- Q323936 wikiPageExternalLink index.html.
- Q323936 wikiPageExternalLink index.html.
- Q323936 wikiPageExternalLink saam2.
- Q323936 wikiPageExternalLink index.html.
- Q323936 wikiPageExternalLink bear.
- Q323936 wikiPageExternalLink jguib.
- Q323936 wikiPageExternalLink www.acslx.com.
- Q323936 wikiPageExternalLink www.admewb.com.
- Q323936 wikiPageExternalLink www.biopharmacy.ethz.ch.
- Q323936 wikiPageExternalLink www.boomer.org.
- Q323936 wikiPageExternalLink phx-wnl.
- Q323936 wikiPageExternalLink www.cloegateway.com.
- Q323936 wikiPageExternalLink www.entelos.com.
- Q323936 wikiPageExternalLink pharmacokinetic-modeling.page.
- Q323936 wikiPageExternalLink processdb.html.
- Q323936 wikiPageExternalLink pmetrics.php.
- Q323936 wikiPageExternalLink software.php.
- Q323936 wikiPageExternalLink overview.
- Q323936 wikiPageExternalLink navigator.
- Q323936 wikiPageExternalLink rapidnca.
- Q323936 wikiPageExternalLink simbiology.
- Q323936 wikiPageExternalLink prod_phoenix_nlme_home.php.
- Q323936 wikiPageExternalLink www.sbpkpd.org.
- Q323936 wikiPageExternalLink www.simcyp.com.
- Q323936 wikiPageExternalLink Products.aspx?grpID=3&cID=16&pID=11.
- Q323936 wikiPageExternalLink equivtest-for-equivalence-testing.
- Q323936 wikiPageExternalLink pksolutions.htm.
- Q323936 wikiPageExternalLink pk-sim.html.
- Q323936 wikiPageExternalLink productsdetail?productId=11962424.
- Q323936 wikiPageExternalLink home.html.
- Q323936 wikiPageExternalLink www.winsaam.com.
- Q323936 wikiPageExternalLink megen.
- Q323936 wikiPageExternalLink mcsim.
- Q323936 wikiPageWikiLink Q1057.
- Q323936 wikiPageWikiLink Q1061104.
- Q323936 wikiPageWikiLink Q1073.
- Q323936 wikiPageWikiLink Q11364.
- Q323936 wikiPageWikiLink Q11369.
- Q323936 wikiPageWikiLink Q11473.
- Q323936 wikiPageWikiLink Q1201513.
- Q323936 wikiPageWikiLink Q12140.
- Q323936 wikiPageWikiLink Q12187.
- Q323936 wikiPageWikiLink Q128406.
- Q323936 wikiPageWikiLink Q1332167.
- Q323936 wikiPageWikiLink Q1412144.
- Q323936 wikiPageWikiLink Q1425437.
- Q323936 wikiPageWikiLink Q1437823.
- Q323936 wikiPageWikiLink Q1468324.
- Q323936 wikiPageWikiLink Q14863039.
- Q323936 wikiPageWikiLink Q14864641.
- Q323936 wikiPageWikiLink Q14864800.
- Q323936 wikiPageWikiLink Q14865120.
- Q323936 wikiPageWikiLink Q155954.
- Q323936 wikiPageWikiLink Q156598.
- Q323936 wikiPageWikiLink Q161973.
- Q323936 wikiPageWikiLink Q16952.
- Q323936 wikiPageWikiLink Q16975484.
- Q323936 wikiPageWikiLink Q170201.
- Q323936 wikiPageWikiLink Q170731.
- Q323936 wikiPageWikiLink Q1758380.
- Q323936 wikiPageWikiLink Q1766412.
- Q323936 wikiPageWikiLink Q1781748.
- Q323936 wikiPageWikiLink Q179217.
- Q323936 wikiPageWikiLink Q180809.
- Q323936 wikiPageWikiLink Q182598.
- Q323936 wikiPageWikiLink Q18352375.
- Q323936 wikiPageWikiLink Q18357603.
- Q323936 wikiPageWikiLink Q185246.
- Q323936 wikiPageWikiLink Q206904.
- Q323936 wikiPageWikiLink Q209082.
- Q323936 wikiPageWikiLink Q216935.
- Q323936 wikiPageWikiLink Q219563.
- Q323936 wikiPageWikiLink Q2256694.
- Q323936 wikiPageWikiLink Q22695562.
- Q323936 wikiPageWikiLink Q2272286.
- Q323936 wikiPageWikiLink Q22906986.
- Q323936 wikiPageWikiLink Q230899.
- Q323936 wikiPageWikiLink Q238512.
- Q323936 wikiPageWikiLink Q240642.
- Q323936 wikiPageWikiLink Q249619.
- Q323936 wikiPageWikiLink Q2562769.
- Q323936 wikiPageWikiLink Q29548.
- Q323936 wikiPageWikiLink Q3009547.
- Q323936 wikiPageWikiLink Q32089.
- Q323936 wikiPageWikiLink Q325519.
- Q323936 wikiPageWikiLink Q3382998.
- Q323936 wikiPageWikiLink Q35497.
- Q323936 wikiPageWikiLink Q367700.
- Q323936 wikiPageWikiLink Q37105.
- Q323936 wikiPageWikiLink Q371522.
- Q323936 wikiPageWikiLink Q3739665.
- Q323936 wikiPageWikiLink Q38344.
- Q323936 wikiPageWikiLink Q40056.
- Q323936 wikiPageWikiLink Q40397.