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- Q3156953 subject Q8416564.
- Q3156953 subject Q8431759.
- Q3156953 abstract "JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi. The chemical structure was inspired by patent of similar BET inhibitors by Mitsubishi Tanabe Pharma [WO/2009/084693]. Structurally it is related to benzodiazepines. While widely used in laboratory applications, JQ1 is not itself being used in human clinical trials because it has a short half life.".
- Q3156953 casNumber "1268524-70-4".
- Q3156953 iupacName "(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate".
- Q3156953 pubchem "46907787".
- Q3156953 thumbnail JQ1.svg?width=300.
- Q3156953 wikiPageWikiLink Q15787.
- Q3156953 wikiPageWikiLink Q17853316.
- Q3156953 wikiPageWikiLink Q18031157.
- Q3156953 wikiPageWikiLink Q18032701.
- Q3156953 wikiPageWikiLink Q18037206.
- Q3156953 wikiPageWikiLink Q1829843.
- Q3156953 wikiPageWikiLink Q6955667.
- Q3156953 wikiPageWikiLink Q83871.
- Q3156953 wikiPageWikiLink Q8416564.
- Q3156953 wikiPageWikiLink Q8431759.
- Q3156953 wikiPageWikiLink Q949861.
- Q3156953 casNumber "1268524".
- Q3156953 iupacName "-tert-butyl 2-acetate".
- Q3156953 pubchem "46907787".
- Q3156953 type ChemicalSubstance.
- Q3156953 type Drug.
- Q3156953 type ChemicalObject.
- Q3156953 type Thing.
- Q3156953 type Q8386.
- Q3156953 comment "JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi.".
- Q3156953 label "JQ1".
- Q3156953 depiction JQ1.svg.