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- Q30679 subject Q6961932.
- Q30679 subject Q7069096.
- Q30679 abstract "Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about an average of 2000 nuclear pore complexes (NPCs), in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The proteins that make up the nuclear pore complex are known as nucleoporins. About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. Each NPC contains at least 456 individual protein molecules and is composed of 30 distinct proteins (nucleoporins). The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered secondary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine—glycine repeats.Nuclear pore complexes allow the transport of molecules across the nuclear envelope. This transport includes RNA and ribosomal proteins moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signaling molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second. Although smaller molecules simply diffuse through the pores, larger molecules may be recognized by specific signal sequences and then be diffused with the help of nucleoporins into or out of the nucleus. It has been recently shown that these nucleoporins have specific evolutionary conserved features encoded in their sequences that provide insight into how they regulate the transport of molecules through the nuclear pore. Nucleoporin-mediated transport is not directly energy requiring, but depends on concentrations gradients associated with the RAN cycle. Each of the eight protein subunits surrounding the actual pore (the outer ring) projects a spoke-shaped protein over the pore channel. The center of the pore often appears to contain a plug-like structure. It is yet unknown whether this corresponds to an actual plug or is merely cargo caught in transit.".
- Q30679 thumbnail Diagram_human_cell_nucleus.svg?width=300.
- Q30679 wikiPageExternalLink nuclearporecomplex.
- Q30679 wikiPageExternalLink nuclearporecomplex2.
- Q30679 wikiPageExternalLink NCDIR%20-%20National%20Center%20for%20the%20Dynamic%20Interactome.
- Q30679 wikiPageExternalLink nuclear%20pore.
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- Q30679 wikiPageWikiLink Q180951.
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- Q30679 wikiPageWikiLink Q210973.
- Q30679 wikiPageWikiLink Q215980.
- Q30679 wikiPageWikiLink Q284578.
- Q30679 wikiPageWikiLink Q304618.
- Q30679 wikiPageWikiLink Q310899.
- Q30679 wikiPageWikiLink Q3195879.
- Q30679 wikiPageWikiLink Q3266476.
- Q30679 wikiPageWikiLink Q3408242.
- Q30679 wikiPageWikiLink Q3571630.
- Q30679 wikiPageWikiLink Q392227.
- Q30679 wikiPageWikiLink Q40260.
- Q30679 wikiPageWikiLink Q42244.
- Q30679 wikiPageWikiLink Q424506.
- Q30679 wikiPageWikiLink Q465608.
- Q30679 wikiPageWikiLink Q483261.
- Q30679 wikiPageWikiLink Q5058349.
- Q30679 wikiPageWikiLink Q620730.
- Q30679 wikiPageWikiLink Q6528191.
- Q30679 wikiPageWikiLink Q654718.
- Q30679 wikiPageWikiLink Q6961932.
- Q30679 wikiPageWikiLink Q7069096.
- Q30679 wikiPageWikiLink Q719725.
- Q30679 wikiPageWikiLink Q7557630.
- Q30679 wikiPageWikiLink Q8054.
- Q30679 wikiPageWikiLink Q835950.
- Q30679 wikiPageWikiLink Q898273.
- Q30679 wikiPageWikiLink Q899827.
- Q30679 wikiPageWikiLink Q910966.
- Q30679 name "Nuclear pore".
- Q30679 type AnatomicalStructure.
- Q30679 type Thing.
- Q30679 type Q4936952.
- Q30679 comment "Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about an average of 2000 nuclear pore complexes (NPCs), in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The proteins that make up the nuclear pore complex are known as nucleoporins.".
- Q30679 label "Nuclear pore".
- Q30679 seeAlso Q19597280.
- Q30679 depiction Diagram_human_cell_nucleus.svg.
- Q30679 name "Nuclear pore".