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- Q3023727 subject Q14957164.
- Q3023727 subject Q15635439.
- Q3023727 subject Q16816272.
- Q3023727 subject Q7158318.
- Q3023727 subject Q7173223.
- Q3023727 subject Q7323268.
- Q3023727 subject Q8602375.
- Q3023727 subject Q8843557.
- Q3023727 subject Q8971959.
- Q3023727 abstract "N-Nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen, and teratogen. NMU is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to AT:GC transition mutations.NMU is the traditional precursor in the synthesis of diazomethane. However, because it is unstable at temperatures beyond 20 °C and somewhat shock-sensitive, it has become obsolete for this purpose and replaced by other N-nitroso compounds: (N-methyl)nitrosamides and nitrosamines. Most chemical supply houses have stopped carrying it.Acute exposure to NMU in humans can result in skin and eye irritation, headache, nausea, and vomiting. NMU is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals (IARC 1972, 1978, 1987). Various cancers induced in animal models include: squamous cell carcinomas of the forestomach, sarcomas and gliomas of the brain, adenocarcinomas of the pancreas, mammary carcinomas, leukemia, and lymphomas. However, the actual potential for human exposure is quite limited, as the chemical is not produced or used in large quantities NMU is teratogenic and embryotoxic, resulting in craniofacial (cleft palate) and skeletal defects, fetal growth retardation, and increased fetal resorption. Exposure to NMU during pre-implantation, post-implantation, organogenesis, or by paternal exposure can result in these effects.".
- Q3023727 iupacName "1-Methyl-1-nitrosourea".
- Q3023727 thumbnail N-Methyl_N-nitroso_urea_structure.svg?width=300.
- Q3023727 wikiPageWikiLink Q1101322.
- Q3023727 wikiPageWikiLink Q123619.
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- Q3023727 wikiPageWikiLink Q138742.
- Q3023727 wikiPageWikiLink Q14957164.
- Q3023727 wikiPageWikiLink Q15635439.
- Q3023727 wikiPageWikiLink Q1606712.
- Q3023727 wikiPageWikiLink Q16816272.
- Q3023727 wikiPageWikiLink Q187661.
- Q3023727 wikiPageWikiLink Q208414.
- Q3023727 wikiPageWikiLink Q221696.
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- Q3023727 wikiPageWikiLink Q356033.
- Q3023727 wikiPageWikiLink Q409298.
- Q3023727 wikiPageWikiLink Q413683.
- Q3023727 wikiPageWikiLink Q413779.
- Q3023727 wikiPageWikiLink Q422960.
- Q3023727 wikiPageWikiLink Q4407.
- Q3023727 wikiPageWikiLink Q552168.
- Q3023727 wikiPageWikiLink Q631521.
- Q3023727 wikiPageWikiLink Q7158318.
- Q3023727 wikiPageWikiLink Q7173223.
- Q3023727 wikiPageWikiLink Q7323268.
- Q3023727 wikiPageWikiLink Q8602375.
- Q3023727 wikiPageWikiLink Q8843557.
- Q3023727 wikiPageWikiLink Q8971959.
- Q3023727 iupacname "1".
- Q3023727 name "N-Nitroso-N-methylurea".
- Q3023727 type ChemicalCompound.
- Q3023727 type ChemicalSubstance.
- Q3023727 type ChemicalObject.
- Q3023727 type Thing.
- Q3023727 type Q11173.
- Q3023727 comment "N-Nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen, and teratogen. NMU is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to AT:GC transition mutations.NMU is the traditional precursor in the synthesis of diazomethane.".
- Q3023727 label "N-Nitroso-N-methylurea".
- Q3023727 depiction N-Methyl_N-nitroso_urea_structure.svg.
- Q3023727 name "N-Nitroso-N-methylurea".