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- Q2964503 subject Q13249712.
- Q2964503 subject Q7204727.
- Q2964503 subject Q7211675.
- Q2964503 subject Q8893046.
- Q2964503 abstract "Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis in the laboratory of Edward M. De Robertis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.In mice, Chordin is expressed in the node but not in the anterior visceral endoderm. It has been found to be required for forebrain development. In developing mice that are deficient in both chordin and noggin, the head is nearly absent. This is significant because when only noggin is deficient there are mild defects but the head still forms.In humans, the chordin peptide is encoded by the CHRD gene.Chordin is also involved in avian gastrulation. It is expressed in the anterior cells of Koller's sickle, which form the anterior cells of the primitive streak, a key structure through which gastrulation occurs.".
- Q2964503 arm "q".
- Q2964503 band "27".
- Q2964503 chromosome "3".
- Q2964503 entrezgene "8646".
- Q2964503 hgncid "1949".
- Q2964503 omim "603475".
- Q2964503 refseq "NM_003741".
- Q2964503 symbol "CHRD".
- Q2964503 uniprot "Q9H2X0".
- Q2964503 wikiPageWikiLink Q1129238.
- Q2964503 wikiPageWikiLink Q13249712.
- Q2964503 wikiPageWikiLink Q172847.
- Q2964503 wikiPageWikiLink Q18252680.
- Q2964503 wikiPageWikiLink Q245204.
- Q2964503 wikiPageWikiLink Q247512.
- Q2964503 wikiPageWikiLink Q25241.
- Q2964503 wikiPageWikiLink Q331858.
- Q2964503 wikiPageWikiLink Q33196.
- Q2964503 wikiPageWikiLink Q385009.
- Q2964503 wikiPageWikiLink Q425383.
- Q2964503 wikiPageWikiLink Q488415.
- Q2964503 wikiPageWikiLink Q507027.
- Q2964503 wikiPageWikiLink Q5344257.
- Q2964503 wikiPageWikiLink Q609809.
- Q2964503 wikiPageWikiLink Q6427377.
- Q2964503 wikiPageWikiLink Q654718.
- Q2964503 wikiPageWikiLink Q7187.
- Q2964503 wikiPageWikiLink Q7204727.
- Q2964503 wikiPageWikiLink Q7211675.
- Q2964503 wikiPageWikiLink Q8054.
- Q2964503 wikiPageWikiLink Q8893046.
- Q2964503 wikiPageWikiLink Q958938.
- Q2964503 arm "q".
- Q2964503 band "27".
- Q2964503 chromosome "3".
- Q2964503 entrezgene "8646".
- Q2964503 hgncid "1949".
- Q2964503 omim "603475".
- Q2964503 refseq "NM_003741".
- Q2964503 symbol "CHRD".
- Q2964503 uniprot "Q9H2X0".
- Q2964503 type Biomolecule.
- Q2964503 type Protein.
- Q2964503 type Thing.
- Q2964503 type Q206229.
- Q2964503 type Q8054.
- Q2964503 comment "Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis in the laboratory of Edward M. De Robertis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins.".
- Q2964503 label "Chordin".