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- Q2964079 subject Q8285617.
- Q2964079 subject Q8395748.
- Q2964079 abstract "Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes. A histidine residue, located in the C-terminal section of the enzyme, plays a central role in its catalytic mechanism.The crystal structure of the type III enzyme from Escherichia coli with chloramphenicol bound has been determined. CAT is a trimer of identical subunits (monomer Mr 25,000) and the trimeric structure is stabilised by a number of hydrogen bonds, some of which result in the extension of a beta-sheet across the subunit interface. Chloramphenicol binds in a deep pocket located at the boundary between adjacent subunits of the trimer, such that the majority of residues forming the binding pocket belong to one subunit while the catalytically essential histidine belongs to the adjacent subunit. His195 is appropriately positioned to act as a general base catalyst in the reaction, and the required tautomeric stabilisation is provided by an unusual interaction with a main-chain carbonyl oxygen.".
- Q2964079 symbol "CAT".
- Q2964079 thumbnail Chloramphenicol_acetyltransferase_3CLA_transparent.png?width=300.
- Q2964079 wikiPageWikiLink Q10876.
- Q2964079 wikiPageWikiLink Q12187.
- Q2964079 wikiPageWikiLink Q25419.
- Q2964079 wikiPageWikiLink Q274515.
- Q2964079 wikiPageWikiLink Q42244.
- Q2964079 wikiPageWikiLink Q481808.
- Q2964079 wikiPageWikiLink Q715317.
- Q2964079 wikiPageWikiLink Q7251510.
- Q2964079 wikiPageWikiLink Q746133.
- Q2964079 wikiPageWikiLink Q8047.
- Q2964079 wikiPageWikiLink Q8285617.
- Q2964079 wikiPageWikiLink Q8395748.
- Q2964079 ecNumber "2.3".
- Q2964079 name "Chloramphenicol acetyltransferase".
- Q2964079 symbol "CAT".
- Q2964079 type Biomolecule.
- Q2964079 type Protein.
- Q2964079 type Thing.
- Q2964079 type Q206229.
- Q2964079 type Q8054.
- Q2964079 comment "Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes.".
- Q2964079 label "Chloramphenicol acetyltransferase".
- Q2964079 depiction Chloramphenicol_acetyltransferase_3CLA_transparent.png.