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- Q2892805 subject Q10103575.
- Q2892805 subject Q7169262.
- Q2892805 subject Q7348611.
- Q2892805 subject Q8521187.
- Q2892805 abstract "Proteostasis, a portmanteau of the words protein and homeostasis, is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking and degradation of proteins present within and outside the cell. The concept of proteostasis maintenance is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associated degenerative disorders. Therefore, adapting proteostasis should enable the restoration of proteostasis once its loss leads to pathology. Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to environmental stresses, and to minimize homeostasis perturbations by pathogens such as viruses. Mechanisms by which proteostasis is ensured include regulated protein translation, chaperone assisted protein folding and protein degradation pathways. Adjusting each of these mechanisms to the demand for proteins is essential to maintain all cellular functions relying on a correctly folded proteome.".
- Q2892805 wikiPageExternalLink www.proteostasis.com.
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- Q2892805 wikiPageWikiLink Q4915012.
- Q2892805 wikiPageWikiLink Q5924361.
- Q2892805 wikiPageWikiLink Q7169262.
- Q2892805 wikiPageWikiLink Q7251235.
- Q2892805 wikiPageWikiLink Q7348611.
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- Q2892805 wikiPageWikiLink Q8521187.
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- Q2892805 wikiPageWikiLink Q898273.
- Q2892805 wikiPageWikiLink Q904984.
- Q2892805 comment "Proteostasis, a portmanteau of the words protein and homeostasis, is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking and degradation of proteins present within and outside the cell.".
- Q2892805 label "Proteostasis".