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- Q288311 subject Q8419806.
- Q288311 abstract "Rhodococcus is a genus of aerobic, nonsporulating, nonmotile Gram-positive bacteria closely related to Mycobacterium and Corynebacterium. While a few species are pathogenic, most are benign, and have been found to thrive in a broad range of environments, including soil, water, and eukaryotic cells. Fully sequenced in October 2006, the genome is known to be 9.7 megabasepairs long and 67% G/C.Strains of Rhodococcus are important owing to their ability to catabolize a wide range of compounds and produce bioactive steroids, acrylamide, and acrylic acid, and their involvement in fossil fuel biodesulfurization. This genetic and catabolic diversity is not only due to the large bacterial chromosome, but also to the presence of three large linear plasmids. Rhodococcus is also an experimentally advantageous system owing to a relatively fast growth rate and simple developmental cycle, but is not well characterized.Another important application of Rhodococcus comes from bioconversion, using biological systems to convert cheap starting material into more valuable compounds, such as its ability to metabolize harmful environmental pollutants, including toluene, naphthalene, herbicides, and PCBs. Rhodococcus species typically metabolize aromatic substrates by first oxygenating the aromatic ring to form a diol (two alcohol groups). Then, the ring is cleaved with intra/extradiol mechanisms, opening the ring and exposing the substrate to further metabolism. Since the chemistry is very stereospecific, the diols are created with predictable chirality. While controlling the chirality of chemical reaction presents a significant challenge for synthetic chemists, biological processes can be used instead to faithfully produce chiral molecules in cases where direct chemical synthesis is not feasible or efficient. An example of this is the use of Rhodococcus to produce indene, a precursor to the AIDS drug indinavir, a protease inhibitor, and containing two of the five chiral centers needed in the complex.".
- Q288311 family Q141145.
- Q288311 kingdom Q10876.
- Q288311 order Q343452.
- Q288311 order Q3817566.
- Q288311 phylum Q130914.
- Q288311 thumbnail Rhodococcus_species.jpg?width=300.
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- Q288311 wikiPageWikiLink Q8419806.
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- Q288311 familia Q141145.
- Q288311 name "Rhodococcus".
- Q288311 ordo Q343452.
- Q288311 phylum Q130914.
- Q288311 regnum Q10876.
- Q288311 subordo Q3817566.
- Q288311 type Species.
- Q288311 type Thing.
- Q288311 comment "Rhodococcus is a genus of aerobic, nonsporulating, nonmotile Gram-positive bacteria closely related to Mycobacterium and Corynebacterium. While a few species are pathogenic, most are benign, and have been found to thrive in a broad range of environments, including soil, water, and eukaryotic cells.".
- Q288311 label "Rhodococcus".
- Q288311 depiction Rhodococcus_species.jpg.
- Q288311 name "Rhodococcus".