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- Q2879363 subject Q13245314.
- Q2879363 subject Q18924462.
- Q2879363 subject Q5856563.
- Q2879363 subject Q7335401.
- Q2879363 subject Q8461197.
- Q2879363 abstract "Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum or Indian trumpetflower. It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement believed to enhance liver health.Baicalein, along with its analogue baicalin, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. In accordance, baicalein shows anxiolytic effects in mice without incidence of sedation or myorelaxation. It is thought that baicalein, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora. Baicalein is also an antagonist of the estrogen receptor, or an antiestrogen.The flavonoid has been shown to inhibit certain types of lipoxygenases and act as an anti-inflammatory agent. It has antiproliferative effects on ET-1-induced proliferation of pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression. Possible antidepressant effects have also been attributed to baicalein in animal research.Baicalein is an inhibitor of CYP2C9, an enzyme of the cytochrome P450 system that metabolizes drugs in the body.A derivative of baicalin is a known prolyl endopeptidase inhibitor.".
- Q2879363 iupacName "5,6,7-Trihydroxy-2-phenyl-chromen-4-one".
- Q2879363 thumbnail Baicalein.svg?width=300.
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- Q2879363 wikiPageWikiLink Q18924462.
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- Q2879363 wikiPageWikiLink Q5856563.
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- Q2879363 iupacname "567".
- Q2879363 type ChemicalCompound.
- Q2879363 type ChemicalSubstance.
- Q2879363 type ChemicalObject.
- Q2879363 type Thing.
- Q2879363 type Q11173.
- Q2879363 comment "Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum or Indian trumpetflower. It is the aglycone of baicalin.".
- Q2879363 label "Baicalein".
- Q2879363 depiction Baicalein.svg.