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- Q2738985 abstract "The prolactin receptor (PRLR)—encoded by a gene on chromosome 5p13-14—interacts with prolactin as a transmembrane receptor. Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region. The PRLR also binds and is activated by growth hormone (GH) and human placental lactogen (hPL) in addition to prolactin.The PRLR is a cytokine receptor, and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway, Ras-Raf-MAPK, and PI3K/AKT/mTOR pathway.The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.".
- Q2738985 arm "p".
- Q2738985 band "13".
- Q2738985 chromosome "5".
- Q2738985 entrezgene "5618".
- Q2738985 hgncid "9446".
- Q2738985 locusSupplementaryData "-p12".
- Q2738985 omim "176761".
- Q2738985 pdb "1RW5".
- Q2738985 refseq "NM_000949".
- Q2738985 symbol "PRLR".
- Q2738985 uniprot "P16471".
- Q2738985 wikiPageWikiLink Q11995.
- Q2738985 wikiPageWikiLink Q1364740.
- Q2738985 wikiPageWikiLink Q189961.
- Q2738985 wikiPageWikiLink Q190199.
- Q2738985 wikiPageWikiLink Q21163349.
- Q2738985 wikiPageWikiLink Q2476074.
- Q2738985 wikiPageWikiLink Q422277.
- Q2738985 wikiPageWikiLink Q7119288.
- Q2738985 wikiPageWikiLink Q899814.
- Q2738985 wikiPageWikiLink Q902835.
- Q2738985 wikiPageWikiLink Q968436.
- Q2738985 arm "p".
- Q2738985 band "13".
- Q2738985 chromosome "5".
- Q2738985 entrezgene "5618".
- Q2738985 hgncid "9446".
- Q2738985 locussupplementarydata "-p12".
- Q2738985 name "prolactin receptor".
- Q2738985 omim "176761".
- Q2738985 pdb "1".
- Q2738985 refseq "NM_000949".
- Q2738985 symbol "PRLR".
- Q2738985 uniprot "P16471".
- Q2738985 type Biomolecule.
- Q2738985 type Protein.
- Q2738985 type Thing.
- Q2738985 type Q206229.
- Q2738985 type Q8054.
- Q2738985 comment "The prolactin receptor (PRLR)—encoded by a gene on chromosome 5p13-14—interacts with prolactin as a transmembrane receptor. Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.".
- Q2738985 label "Prolactin receptor".
- Q2738985 name "prolactin receptor".